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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 70巻1号

Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuroprotective potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol

http://hdl.handle.net/10129/00006847
http://hdl.handle.net/10129/00006847
0e9dfbcd-53d6-435b-9cf4-c64f068d9c55
名前 / ファイル ライセンス アクション
HirosakiMedJ_70(1)_24.pdf HirosakiMedJ_70(1)_24 (420.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-11-22
タイトル
タイトル Effect of low-concentration amyloid-β 1–42 (Aβ42) on human neuroblastoma SH-SY5Y cell viability: neuroprotective potential of combination use with carnosic acid, rebamipide, edaravone, and resveratrol
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 low-concentration Aβ42
キーワード
主題Scheme Other
主題 cell viability
キーワード
主題Scheme Other
主題 combination treatment
キーワード
主題Scheme Other
主題 SH-SY5Y cells
キーワード
主題Scheme Other
主題 Alzheimer’s disease
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Yoshida, Hidemi

× Yoshida, Hidemi

en Yoshida, Hidemi

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Hashimoto, Yuko

× Hashimoto, Yuko

en Hashimoto, Yuko

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Fukushima, Takashi

× Fukushima, Takashi

en Fukushima, Takashi

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Tanji, Kunikazu

× Tanji, Kunikazu

en Tanji, Kunikazu

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Matsumiya, Tomoh

× Matsumiya, Tomoh

en Matsumiya, Tomoh

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Seya, Kazuhiko

× Seya, Kazuhiko

en Seya, Kazuhiko

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Kawaguchi, Shogo

× Kawaguchi, Shogo

en Kawaguchi, Shogo

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Imaizumi, Tadaatsu

× Imaizumi, Tadaatsu

en Imaizumi, Tadaatsu

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著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Neuropathology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology Institute of Brain Science, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 Toxic amyloid-beta (Aβ) is known to generate symptoms of Alzheimer’s disease (AD); however, less is known regarding the neurotoxicity of Aβ at lower concentrations. Moreover, the neuroprotective potential of combination treatment with plant biophenols and existing drugs is not well understood. In this study, we estimated the no-observed adverse effect level (NOAEL) of Aβ 1–42 (Aβ42) against cultured human neuroblastoma SHSY5Y cells, and examined the neuroprotective effect of combination pretreatment with 10 μM carnosic acid, 30 nM rebamipide, 10 μM edaravone, and 10 μM of resveratrol (the “CRER” blend) on weak but toxic Aβ42-treated SH-SY5Y cells. We evaluated the NOAEL of Aβ42 at 500 nM in these cells. Aβ42 at 1–8 μM reduced cell viability; however, the “CRER” blend ameliorated this Aβ42-induced decrease in viability. The “CRER” blend induced the expression of Aβ-degrading enzymes including matrix metalloproteinase-14 (MMP-14) and neprilysin, while also enhancing the expression of the inducible α-secretase TACE (tumor necrosis factor-α-converting enzyme), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor( BDNF). Collectively, our results indicate that the “CRER” may aid in the prevention of Aβ toxicity by enhancing MMP-14, neprilysin, TACE, SIRT1, and BDNF. Thus, the “CRER” blend may prove to be a promising strategy for the prevention of Aβ-mediated disorders, particularly AD.
書誌情報 ja : 弘前医学

巻 70, 号 1, p. 24-38, 発行日 2019-11-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
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