WEKO3
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Additional Effect in Reduction of Albuminuria Due to the Combination Therapy of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Type 1 Receptor Blocker in Type 2 Diabetic Patients with the Angiotensinogen 235T Allele
http://hdl.handle.net/10129/695
http://hdl.handle.net/10129/695212e78f2-94b1-4833-95ea-d7a9dddb92e2
名前 / ファイル | ライセンス | アクション |
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AN00211444_59_59.pdf (395.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-07-27 | |||||
タイトル | ||||||
タイトル | Additional Effect in Reduction of Albuminuria Due to the Combination Therapy of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Type 1 Receptor Blocker in Type 2 Diabetic Patients with the Angiotensinogen 235T Allele | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | renin-angiotensin system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiotensinogen 235T allele | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | type 2 diabetic nephropathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiotensin-converting-enzyme inhibitor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | angiotensin II type 1 receptor blocker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | レニン-アンギオテンシン-アルドステロン系 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アンギオテンシノーゲン遺伝子235T allele | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アンギオテンシン変換酵素阻害薬 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アンギオテンシンII受容体拮抗薬 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Matsui, Jun
× Matsui, Jun× Ogawa, Yoshiji× Tamasawa, Naoki× Yamashita, Maki× Matsuki, Kota× Tanabe, Jutaro× Murakami, Hiroshi× Suda, Toshihiro |
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著者(ヨミ) | ||||||
姓名 | マツイ, ジュン | |||||
著者(ヨミ) | ||||||
姓名 | オガワ, ヨシジ | |||||
著者(ヨミ) | ||||||
姓名 | タマサワ, ナオキ | |||||
著者(ヨミ) | ||||||
姓名 | ヤマシタ, マキ | |||||
著者(ヨミ) | ||||||
姓名 | マツキ, コウタ | |||||
著者(ヨミ) | ||||||
姓名 | タナベ, ジュタロウ | |||||
著者(ヨミ) | ||||||
姓名 | ムラカミ, ヒロシ | |||||
著者(ヨミ) | ||||||
姓名 | スダ, トシヒロ | |||||
著者別名 | ||||||
姓名 | 松井, 淳 | |||||
著者別名 | ||||||
姓名 | 小川, 吉司 | |||||
著者別名 | ||||||
姓名 | 玉澤, 直樹 | |||||
著者別名 | ||||||
姓名 | 山下, 真紀 | |||||
著者別名 | ||||||
姓名 | 松木, 恒太 | |||||
著者別名 | ||||||
姓名 | 田辺, 壽太郎 | |||||
著者別名 | ||||||
姓名 | 村上, 宏 | |||||
著者別名 | ||||||
姓名 | 須田, 俊宏 | |||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科内分泌代謝内科学講座 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the combination therapy of angiotensin-converting-enzyme inhibitor (ACE-I) and angiotensin II type 1 receptor blocker (ARB) offered an additional effect in reduction of albuminuria in type 2 diabetic patients with angiotensinogen (AGT) M235T polymorphism. The study subjects were type 2 diabetic patients with nephropathy who were attending Hirosaki University Hospital. Fifteen patients with 235T allele (TT genotype 9, MT genotype 6) were evaluated who had diabetic nephropathy in stage 2 or 3 and already treated with ACE-I. Each patient administrated ARB (20-40 mg of termisartan) in addition to ACE-I for 16 weeks as the combination therapy. The addition of termisartan induced a significant reduction in systolic blood pressure (BP) of 14.0 mmHg and diastolic BP of 5.4mmHg. The urinary albumin-creatinine ratio (ACR) was also reduced to 48.9%. There was no significant correlation between the reduction rate of ACR and the antihypertensive response of systolic blood pressure (BP) (rs = 0.1277) and of diastolic BP (rs=0.1420) by the addition of termisartan. These results indicated that the combination of ACE-I and ARB had an additional effect on urinary albumin excretion in type 2 diabetic patients with AGT 235T allele. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 59, 2008, p.59-64 | |||||
書誌情報 |
弘前医学 巻 59, 号 2/3/4, p. 59-64, 発行日 2008-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 493.1 | |||||
その他のタイトル | ||||||
その他のタイトル | アンギオテンシノーゲン遺伝子235T alleleを有する2型糖尿病腎症患者におけるACE阻害剤とARB併用によるアルブミン尿改善効果 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | アンギオテンシノーゲン イデンシ 235T allete オ ユウスル 2ガタ トウニョウビョウ ジンショウ カンジャ ニ オケル ACE ソガイザイ ト ARB ヘイヨウ ニヨル アルブミンニョウ カイゼン コウカ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |