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Factors associated with the effect of anamorelin on cachexia in patients with non-small cell lung cancer
http://hdl.handle.net/10129/0002000735
http://hdl.handle.net/10129/00020007355846350d-7e4b-4804-9668-441e7721ee88
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本文 (313 KB)
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内容要旨 (169 KB)
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審査要旨 (177 KB)
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| Item type | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||
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| 公開日 | 2025-01-14 | |||||||
| タイトル | ||||||||
| タイトル | Factors associated with the effect of anamorelin on cachexia in patients with non-small cell lung cancer | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | anamorelin | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | cachexia | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | NSCLC | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子（シンプル） | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ（シンプル） | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
石岡, 佳子
× 石岡, 佳子
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| 内容記述タイプ | Abstract | |||||||
| 内容記述 | PURPOSE: Anamorelin, a ghrelin receptor agonist, is approved in Japan for the treatment of cachexia in patients with lung and gastrointestinal cancer. However, there is limited research on the usefulness of anamorelin in clinical settings. METHODS: A total of 40 patients with non-small cell lung cancer and cachexia who were prescribed anamorelin between July 2021 and November 2022, were retrospectively assessed. A logistic regression analysis was used to analyze the association between background characteristics and early discontinuation of treatment with anamorelin （within 4 weeks）. RESULTS: The median age was 67 years （range, 36-88）, and 65% of the patients were male. The early discontinuation group included 11 patients （27.5%）. An Eastern Cooperative Oncology Group Performance Status （ECOG-PS） score 2 （odds ratio, 7.85; 95% confidence interval, 1.43-43.21; P=0.018） was associated with early discontinuation. A total of 18/40 patients were able to continue anamorelin treatment for 12 weeks, and the mean change in body weight was +2.31 kg, which was a significant change from the weight recorded at baseline（ P=0.027）. CONCLUSION: This study indicates that anamorelin is unlikely to be useful for patients with a poor general condition（ ECOG-PS score 2）. |
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| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author: Yoshiko Ishioka, Hisashi Tanaka, Tomonori Makiguchi, Hiroaki Sakamoto, Toshihiro Shiratori, Kageaki Taima, Sadatomo Tasaka | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Hirosaki Medical Journal 75：22-30，2024 | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : Hirosaki Medical Journal 巻 75, 号 1, p. 22-30, 発行日 2024-10-30 |
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| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2434-4656 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00211444 | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 出版者 | ||||||||
| 出版者 | 弘前大学出版会 | |||||||
| 言語 | ja | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士（医学） | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 11101 | |||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 弘前大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2024-09-30 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 乙第895号 | |||||||
