| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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|
タイトル |
Effects of proinfl ammatory cytokines on intracellular glucocorticoid metabolism |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Iwasaki, Yasumasa
Tsugita, Makoto
Taniguchi, Yoshimori
Nigawara, Takeshi
Takayasu, Shinobu
Kawahara, Masayuki
Suda, Toshihiro
Hashimoto, Kozo
|
| 著者所属 |
|
|
値 |
Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University |
| 著者所属 |
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|
値 |
Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University |
| 著者所属 |
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|
値 |
Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University |
| 著者所属 |
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|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Cytokines is known to infl uence hormone synthesis and secretion. Indeed, some of the proinfl ammatorycytokines stimulate hormone release at the hypothalamic, pituitary, and peripheral endocrine organs. Recently, a newparadigm of immune-endocrine interaction has been emerging. We and others have shown that cytokines modify theeff ectiveness of hormone action. This is occurring via enhancement of receptor-mediated signaling, or modifi cation ofintracellular metabolism of hormones. In the latter case, we found that representative cytokines such as interleukin 1βand TNFα stimulate the expression of the glucocorticoid-activating enzyme 11β- ~ hydroxysteroid dehydrogenase type1（ 11βHSD1） and suppress that of the inactivating enzyme 11βHSD2, thus increasing the intracellular concentrationand action of glucocorticoids. In vascular smooth muscle cells, this mechanism is advantageous in preventing vascularcollapse during sepsis. We also found that, in hepatocytes, cytokines suppress the expression of the thyroid hormoneactivatingenzyme 5’-deiodinase type I. This may be responsible for the low T3 syndrome in critical illness. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S58-S61 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S58-S61,
発行日 2007-11-29
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491.8 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S62.pdf (218.6 kB)
