| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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タイトル |
Urocortin 2 suppresses host resistance to Listeria monocytogenes infection via up-regulation of IL-10 |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Ucn2 |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Listeria monocytogenes |
| キーワード |
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主題Scheme |
Other |
|
主題 |
IL-10 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sashinami, Hiroshi
Kageyama, Kazunori
Suda, Toshihiro
Nakane, Akio
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| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
It is well known that corticotropin releasing factor （CRF） modulates immune response duringinfl ammation. We investigated the eff ect of CRF family peptides on host resistance to Listeria monocytogenes infectionin mice. The numbers of L. monoctyogenes in the organs of Ucn2-treated mice were dramatically increased comparedwith CRF- or Ucn-treated mice. CRF receptor type 2 is involved in the suppressive eff ect of Ucn2 on L. monocytogenesinfection. Interferon （IFN）-γ and tumor necrosis factor （TNF）-α production were decreased and interleukin （IL）-10 production was signifi cantly increased in the spleens of Ucn2-treated mice compared with those in Ucn2-untreatedcontrol mice. The eff ect of Ucn2 was canceled by depleting endogenous IL-10 using anti-IL-10 monoclonal antibodyand in IL-10 deficient mice. The expression and activation of signal transducers and activators of transcription3 （STAT3） were up-regulated and the expression and activation of STAT1 were down-regulated in the spleensfrom Ucn2-treated mice compared with vehicle-treated mice. Moreover, suppression of TNF-α production andaugmentation of IL-10 production and expression and activation of STAT3 by Ucn2 treatment were observed in heatkilledL. monocytogenes-stimulated macrophages. These results suggested that Urn2 suppresses host resistance to L.monocytogenes infection via up-regulation of IL-10 production. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S67-S76 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S67-S76,
発行日 2007-11-29
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491.8 |
| NIIサブジェクト |
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|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S67.pdf (385.1 kB)
