| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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タイトル |
Vaccination with a nontoxic mutant of staphylococcal enterotoxin C elicits Th2 immune response for protection against Staphylococcus aureus infection |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hu, Dong-Liang
Omoe, Katsuhiko
Narita, Koji
Shinagawa, Kunihiro
Nakane, Akio
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| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
To develop a Staphylococcus aureus vaccine, we constructed and expressed a non-toxic mutant staphylococcalenterotoxin C（ mSEC） and investigated whether immunization with mSEC can protect against S. aureus infection. Micewere immunized with mSEC and challenged with viable S. aureus. Bacteria counts in the organs in mSEC-immunizedmice were significantly lower and the survival rate was higher than those of the control group. mSEC vaccinationinduced the production of T-helper 2 type antibodies. The production of interleukin-10（ IL-10） and IL-4 in vaccinatedmice was signifi cantly higher compared with the control group, whereas the production of gamma interferon （IFN-γ.）was signifi cantly decreased in the vaccinated mice. Furthermore, IFN-γ.and tumor necrosis factor-α・ production in vitrowas signifi cantly inhibited by the sera from mSEC-vaccinated mice but not by those from control mice. These resultssuggest that vaccination with mSEC provides protection against S. aureus infection. SEC neutralizing antibodies and theIL-10 and IL-4 induction might play important role for the protection. |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
弘前医学. 59(Suppl.), 2007, p.S210-S218 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S210-S218,
発行日 2007-11-29
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00211444 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
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主題Scheme |
NDC |
|
主題 |
491 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
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値 |
Article |
HirosakiMedJ_59_S210.pdf (360.1 kB)
