| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-16 |
| タイトル |
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|
タイトル |
＜Syposium II＞Inactivation of voltage-gated Ca^2+ channels and cone-rod dystrophy CORD7 |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
Calcium channel |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
inactivation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neurotransmission |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
RIM |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Calcium channel; inactivCone-Rod Dystrophy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Wakamori, Minoru
Uriu, Yoshitsugu
Miki, Takafumi
Kiyonaka, Shigeki
Mori, Yasuo
|
| 著者所属 |
|
|
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Department of Oral Biology, Tohoku University Graduate School of Dentistry |
| 著者所属 |
|
|
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Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engineering |
| 著者所属 |
|
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Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engineering |
| 著者所属 |
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Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engineering |
| 著者所属 |
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Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engineering |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Active zones are highly specialized sites for release of neurotransmitter in presynaptic nerve terminals. The spacing between voltage-dependent calcium channels（ VDCCs） and synaptic vesicles at active zones is thought to infl uence the dynamic properties of synaptic transmission. Recently we have demonstrated a novel molecular interaction between VDCCs and an active zone scaffolding protein, rab3-interacting molecule 1 （RIM1）. The RIM1 induced a pronounced deceleration of inactivation rate and a depolarizing shift of the inactivation curve of recombinant P/Q-type VDCC expressed as α1Aα2/δβ1a complex in baby hamster kidney cells. During 2-s voltagedisplacement to -30 mV, which is the threshold of the P/Q-type VDCC activation, almost all channels were inactivated in the absence of the RIM1 （closed-state inactivation）, but less than 20% of the channels were inactivated in the presence of the RIM1. Thus, the RIM1 coordinates calcium signaling and spatial organization of molecular constituents at presynaptic active zone.
A mutation has been identified for an autosomal dominant cone-rod dystrophy CORD7 in the RIM1 gene. Interestingly, the aff ected individuals showed signifi cantly enhanced cognitive abilities across a range of domains. The mouse RIM1 arginine-to-histidine substitution （R655H）, which corresponds to the human CORD7 mutation, modifi es RIM1 function in regulating VDCC currents elicited by the P/Q-type Cav2.1 and L-type Cav1.4 channels. The data can raise an interesting possibility that CORD7 phenotypes including retinal defi cits and enhanced cognition are at least partly due to altered regulation of presynaptic VDCC currents. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S53-S62 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S53-S62,
発行日 2010-07-08
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
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主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_61_S53.pdf (288.0 kB)
