| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-16 |
| タイトル |
|
|
タイトル |
＜Symposium III＞Role of Nrf2 in the neurotrophic action of the electrophiles |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Itoh, Ken
Kosaka, Kunio
Mimura, Junsei
Satoh, Takumi
|
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12438 |
|
|
姓名 |
イトウ, ケン |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12439 |
|
|
姓名 |
ミムラ, ジュンセイ |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12440 |
|
|
姓名 |
伊東, 健 |
| 著者所属 |
|
|
|
Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Research and Development Center, Nagase & Co., Ltd. |
| 著者所属 |
|
|
|
Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Welfare Engineering, Faculty of Engineering, Iwate University |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Electrophilic compounds, such as curcumin and neurite outgrowth-promoting prostaglandins （NEPPs）, have been known to enhance neurite outgrowth in the presence of small amounts of nerve growth factor （NGF）in PC12 cells. However, the redox-sensitive molecular target for enhanced neurite outgrowth is largely unknown. NGF exerts its function by binding to the cell surface tyrosine kinase receptor, TrkA. Recently, Shibata et al. reported that PTP1B catalyses the dephosphorylation of TrkA. They also demonstrated that an electrophile from Japanese horseradish Wasabi, 6-methylsulfi nylhexyl isothiocyanate （6-HITC）, inactivates PTP1B causing sustained phosphorylation and activation of TrkA and promoting neural diff erentiation of PC12 cells. Further, we recently discovered that carnosic acid （CA）, a catechol-type electrophilic compound that is a major ingredient in the herb rosemary, strongly promotes neurite outgrowth of PC12h cells by activating the redox-sensitive transcription factor, Nrf2. Activation of Nrf2 by CA caused a marked induction of p62/ZIP, an important signaling scaff old protein for NGF signaling. Unexpectedly, NGF also activates Nrf2, which is essential for NGF-mediated neural diff erentiation. Thus, electrophiles may enhance neural diff erentiation by both TrkA-dependent and -independent mechanisms. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S63-S69 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S63-S69,
発行日 2010-07-08
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_61_S63.pdf (399.5 kB)
