| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-18 |
| タイトル |
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|
タイトル |
＜Poster＞Modulation of neuronal activities by interactions between neurons and glial cells |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
perineuronal glial cell |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
astrocyte |
| キーワード |
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主題Scheme |
Other |
|
主題 |
oligodendrocyte |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
conduction velocity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hippocampus |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yamazaki, Yoshihiko
Hozumi, Yasukazu
Kaneko, Kenya
Fujiwara, Hiroki
Kato, Hiroshi
Fujii, Satoshi
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| 著者所属 |
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Department of Physiology Yamagata University School of Medicine |
| 著者所属 |
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Department of Anatomy & Cell Biology, Yamagata University School of Medicine |
| 著者所属 |
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Department of Physiology Yamagata University School of Medicine |
| 著者所属 |
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Department of Physiology Yamagata University School of Medicine |
| 著者所属 |
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Department of Physiology Yamagata University School of Medicine |
| 著者所属 |
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Department of Physiology Yamagata University School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Action potentials are the fundamental signals for relaying information from one region to another in the nervous system. Action potentials are propagated along axons without decrease of their amplitudes and are conducted with constant velocity depending on axonal diameter and myelin. It is considered that the modulation of firing patterns of action potentials in the neural circuit infl uences the information processing in the brain. We investigated the modulatory eff ects of glial cells on the fi ring pattern and the axonal conduction of action potentials using rat hippocampal slice preparation. In our previous study, we focused on interneuron / perineuronal glial cell pairs in CA1 region and reported that perineuronal glial cells could be classifi ed into two groups, one group belong astrocytes （perineuronal astrocytes） and the other group oligodendrocytes （perineuronal oligodendrocytes）, based on their membrane properties and immunohistochemical study. Direct depolarization of perineuronal astrocytes modulated the directly induced fi ring pattern of the interneuron, with initial facilitation and subsequent suppression. We also studied the oligodendrocytes in the alveus and examined their modulatory effects on the conduction of action potentials along axons of CA1 pyramidal cells. Direct repetitive depolarization of oligodendrocytes shortened the latencies of action potentials evoked by antidromic stimulation. These results indicate that glial cells infl uence the firing pattern and axonal conduction of action potentials, and that their effects involve both facilitation and suppression. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S174-S180 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S174-S180,
発行日 2010-07-08
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
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|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
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|
値 |
Article |
HirosakiMedJ_61_S174.pdf (239.0 kB)
