| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-19 |
| タイトル |
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|
タイトル |
＜Poster＞Cerebrovascular dynamics in response to neural stimulation |
| 言語 |
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言語 |
eng |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
two-photon microscopy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
in vivo optical imaging |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neurovascular coupling |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
functional brain mapping |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Masamoto, Kazuto
Obata, Takayuki
Kanno, Iwao
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| 著者所属 |
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The University of Electro-Communications |
| 著者所属 |
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Molecular Imaging Center, National Institute of Radiological Sciences |
| 著者所属 |
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Molecular Imaging Center, National Institute of Radiological Sciences |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Cerebral blood flow is tightly regulated, and local metabolic demands are met by adjustments to the regional density of microvascular networks and by temporal and spatial changes in microvascular blood flow. Cerebral blood flow regulation may involve communication between and across the vascular cells and neural or glial cells in either rapid or slow conduits. In the present study, we report distinct diff erences between the dynamic reactions of cerebral arterial networks in cortical surface and in intracortical tissue regions in response to sensory stimulation. Using confocal and multi-photon excitation laser scanning fluorescence microscopy, we imaged the cortical surface and subsurface vascular networks in the somatosensory cortex of isoflurane-anesthetized rats. Changes in lumen diameter were imaged at a rate of 13 frames per second with a fi eld of view of 512 by 512 pixels. We consistently observed a stimulus-dependent increase in the lumen diameter of arterial networks in both cortical surface and subsurface regions. The onset time of vasodilation was observed to be ~0.8 sec for the subsurface arterioles（ <40 μm）, which was signifi cantly shorter than the ~1.1 sec vasodilation onset time of the surface arteries （20-120 μm）. The peak dilation accounted for 10% of the pre-stimulus baseline diameter. Further, the propagation of surface arterial vasodilation increased in a stimulus-dependent manner. The results indicate that global vasodilation of upstream parent arteries may be necessary to prevent “blood steal” by inactive regions nearby. Further studies are needed to elucidate the physiological mechanisms underlying the propagation of vasodilation induced by neural stimulation. |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S181-S186 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S181-S186,
発行日 2010-07-08
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
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|
値 |
Article |
HirosakiMedJ_61_S181.pdf (304.7 kB)
