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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 61巻Supplement

<Poster>Effect of a free radical scavenger, edaravone, on free radical reactions : Related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model

http://hdl.handle.net/10129/3688
http://hdl.handle.net/10129/3688
df621d2a-08ed-4204-b8df-aca0a73618ef
名前 / ファイル ライセンス アクション
HirosakiMedJ_61_S197.pdf HirosakiMedJ_61_S197.pdf (110.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-08-19
タイトル
タイトル <Poster>Effect of a free radical scavenger, edaravone, on free radical reactions : Related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model
言語
言語 eng
キーワード
主題Scheme Other
主題 Cerebral vasospasm
キーワード
主題Scheme Other
主題 edaravone
キーワード
主題Scheme Other
主題 free radical scavenger
キーワード
主題Scheme Other
主題 Rho-kinase
キーワード
主題Scheme Other
主題 subarachnoid hemorrhage
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Munakata, Akira

× Munakata, Akira

Munakata, Akira

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著者(ヨミ)
識別子Scheme WEKO
識別子 12559
姓名 ムナカタ, アキラ
著者別名
識別子Scheme WEKO
識別子 12560
姓名 棟方, 聡
著者所属
値 Department of Neurosurgery, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 OBJECTIVE: It is hypothesized that free radical reactions evoked by oxyhemoglobin (oxyHb) cause cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH), even though the detailed mechanisms have not yet been fully established. The aims of this study were thus to investigate, through the use of the doublehemorrhage rabbit model, the possibility that using a potent free radical scavenger, edaravone, will show amelioration of cerebral vasospasm, and to delineate the mechanism of signal transduction that causes cerebral vasospasm.
METHODS: In the SAH group, SAH was simulated using the double-hemorrhage rabbit model. In the treatment group, edaravone (0.6 mg/kg) was injected into the central ear vein. Ninety-six hours after SAH, the basilar artery was excised. The degree of cerebral vasospasm was evaluated by measuring the diameter of each basilar artery, and the expression of Rho-kinase in the vascular wall was examined by Western blotting. RESULTS: The diameter of the basilar artery in the edaravone-treated group was 0.71 ± 0.06 mm, which was statistically signifi cantly larger than that in the nontreated SAH group (0.50 ± 0.03 mm; P < 0.01). The expression of Rho-kinase in the edaravonetreated group was statistically signifi cantly reduced in comparison to that of the nontreated SAH group (P < 0.01).
CONCLUSION: Results from this study indicate that edaravone may potentially serve as an agent in the prevention of cerebral vasospasm in patients after SAH. In addition, it might be suggested that the free radical reaction mediated by oxyHb is concerned with the regulation of the Rho/Rho-kinase pathway.
引用
内容記述タイプ Other
内容記述 弘前医学. 61(Suppl.), 2010, p.S197-S203
書誌情報 弘前医学

巻 61, 号 Supplement, p. S197-S203, 発行日 2010-07-08
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
日本十進分類法
主題Scheme NDC
主題 490
NIIサブジェクト
主題Scheme Other
主題 医学
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
資源タイプ
値 Article
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