| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-19 |
| タイトル |
|
|
タイトル |
＜Poster＞Cystatin C immunoreactivity and neuronal degeneration in amyotrophic lateral sclerosis |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
staphylococcal enterotoxin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
immunization |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
emesis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
house musk shrew |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hu, Dong-Liang
Omoe, Katsuhiko
Sashinami, Hiroshi
Shinagawa, Kunihiro
Nakane, Akio
|
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11493 |
|
|
姓名 |
フウ, ドンリャン |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11495 |
|
|
姓名 |
サシナミ, ヒロシ |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11501 |
|
|
姓名 |
ナカネ, アキオ |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11483 |
|
|
姓名 |
胡, 東良 |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11487 |
|
|
姓名 |
差波, 拓志 |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11492 |
|
|
姓名 |
中根, 明夫 |
| 著者所属 |
|
|
|
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University |
| 著者所属 |
|
|
|
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University |
| 著者所属 |
|
|
|
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background. Staphylococcal enterotoxins （SEs） are the most common cause of food-borne diseases and toxic shock syndrome throughout the world. However, little is known about the mechanism of emesis induced by SEs and no vaccine that prevents SE-induced emesis has been described. Methods. A nontoxic mutant SEA, SEAD227A, was constructed by site-directed mutagenesis and purified from Escherichia coli expression system. House musk shrews, a small emetic animal model, were immunized with SEAD227A and then challenged with wild-type SEA. SEA-induced emesis was recorded for 3 h. Antibody production was analyzed by gel double-immunodiff usion assay. Neutralizing activities of the antibodies to superantigenic and emetic activities were analyzed in vitro and in vivo. Results. SEAD227A was devoid of both superantigenic and emetic activities, but still retained its immunological activity. Immunization with SEAD227A strongly induced specifi c antibody production and signifi cantly provided the protection against SEA-induced emesis. The antibodies from immunized shrews markedly inhibited the SEA-induced proliferation of spleen cells and also significantly ablated the SEA-induced vomiting in the animals. Conclusions. These results suggest that vaccination with SEAD227A devoid of toxic properties provides protection against SEAinduced emesis. This nontoxic mutant and its specifi c antibodies might be useful in the prevention and treatment of staphylococcal food poisoning |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S215-S223 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S215-S223,
発行日 2010-07-08
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_61_S215.pdf (349.8 kB)
