| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-19 |
| タイトル |
|
|
タイトル |
＜Poster＞Mouse peptidoglycan recognition protein（ PGRP）-S : the role in bacterial infection |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PGRP-S |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Listeria monocytogenes |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cytokine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
innate immunity |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Osanai, Arihiro
Li, Sheng-Jun
Nakane, Akio
|
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11496 |
|
|
姓名 |
オサナイ, アリヒロ |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11501 |
|
|
姓名 |
ナカネ, アキオ |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11229 |
|
|
姓名 |
長内, 理大 |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12603 |
|
|
姓名 |
李, 勝軍 |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
11492 |
|
|
姓名 |
中根, 明夫 |
| 著者所属 |
|
|
値 |
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Peptidoglycan recognition proteins （PGRPs） are pattern recognition receptors which are conserved from insects to humans. PGRPs can recognize bacteria and their cell wall components, peptidoglycans. Human PGRPs have bactericidal activities that can be accomplished by their amidase activities. Insect PGRPs consist of 16 subtypes and some have eff ector functions as the activation of Toll pathway （PGRP-SA）, the activation of Imd pathway （PGRPLC）and induction of autophagosome formation （PGRP-LE）, thus contribute to the elimination of bacteria. However, the role of mammalian PGRPs in bacterial infection remains unclear. In this study, we report the function of mouse PGRP-S, the homologue of PGRP-SA, in bacterial infection. The recombinant protein was produced in Escherichia coli overexpression system and used for specifi cantibody production. We investigated the role of PGRP-S in infection with Listeria monocytogenes, a facultative Gram-positive bacterium that can grow intracellularly. The administration of recombinant PGRP-S before L. monocytogenes infection decreased the number of bacteria in the organs of infected mice. When endogenous PGRP-S was neutralized by antibodies specifi c to PGRP-S, the bacterial number increased. The levels of proinfl ammatory cytokines that are essential in the protection against L. monocytogenes infection were lower when the specific antibody was administered prior to infection. Together with these, it is suggested that PGRP-S plays a role in the protection against L. monocytogenes infection. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S232-S237 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S232-S237,
発行日 2010-07-08
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_61_S232.pdf (95.0 kB)
