| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-19 |
| タイトル |
|
|
タイトル |
＜Poster＞Involvement of P2X2 and P2X3 receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
diabetic neuropathy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
DRG |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
P2X |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Migita, Keisuke
Honda, Kenji
Yamada, Junko
Takano, Yukio
Ueno, Shinya
|
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12650 |
|
|
姓名 |
ミギタ, ケイスケ |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12651 |
|
|
姓名 |
ホンダ, ケンジ |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12652 |
|
|
姓名 |
ヤマダ, ジュンコ |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12653 |
|
|
姓名 |
タカノ, ユキオ |
| 著者(ヨミ) |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12654 |
|
|
姓名 |
ウエノ, シンヤ |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12655 |
|
|
姓名 |
右田, 啓介 |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12656 |
|
|
識別子Scheme |
研究者総覧 |
|
|
識別子URI |
http://hue2.jm.hirosaki-u.ac.jp/html/323_ja.html |
|
|
識別子 |
323 |
|
|
姓名 |
山田, 順子 |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
12657 |
|
|
識別子Scheme |
研究者総覧 |
|
|
識別子URI |
http://hue2.jm.hirosaki-u.ac.jp/html/320_ja.html |
|
|
識別子 |
320 |
|
|
姓名 |
上野, 伸哉 |
| 著者所属 |
|
|
|
Department of Neurophysiology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University |
| 著者所属 |
|
|
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Department of Neurophysiology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University |
| 著者所属 |
|
|
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Department of Neurophysiology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Painful diabetic neuropathy causes allodynia and does not respond to commonly used analgesics such as non-steroidal anti-infl ammatory drugs or opioids at doses below those producing disruptive side eff ects. In the present study, we examined the effect of P2X receptor antagonists, which are known to modulate the pain pathway, on mechanical allodynia in streptozotocin（ STZ）-induced diabetic mice. The paw withdrawal frequency measured by von Frey fi laments, began to signifi cantly increase 5 days after STZ injection and was maintained for more than 14 days. Intrathecal administration of P2X receptor antagonists （PPADS and TNP-ATP） inhibited the mechanical allodynia in diabetic mice. Next, the levels of mRNA for the P2X receptors in DRG in diabetic mice were measured using quantitative real-time PCR. The levels of P2X2 and P2X3 receptors mRNA were signifi cantly increased in diabetic mice at 14 days after the intravenous injection of STZ. Furthermore, we investigate the localization of glial cells and neuron in spinal cord of diabetic mice. However, microglia, astrocyte and neuron were not changed in spinal cord. These results suggest that the upregulation of P2X2, P2X3 and/or P2X2/3 receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S255-S261 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S255-S261,
発行日 2010-07-08
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_61_S255.pdf (209.3 kB)
