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A Novel Nrf2-Mediated Antioxidative and Antiinflammatory Mechanism through Ferroportin 1 Induction : A Potential Cytoprotective Mechanism against Ischemia-Reperfusion Injuries
http://hdl.handle.net/10129/4870
http://hdl.handle.net/10129/487081b4c1fb-b318-4d58-b6d7-cdd195d0c49e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_64_S74.pdf (401.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-04-30 | |||||
| タイトル | ||||||
| タイトル | A Novel Nrf2-Mediated Antioxidative and Antiinflammatory Mechanism through Ferroportin 1 Induction : A Potential Cytoprotective Mechanism against Ischemia-Reperfusion Injuries | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Inflammation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Oxidative stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Iron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nrf2 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Harada, Nobuhiko
× Harada, Nobuhiko× Matsuura, Shin× Kanayama, Masaya× Yoshida, Aruto× Itoh, Ken |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 13823 | |||||
| 姓名 | ハラダ, ノブヒコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 13824 | |||||
| 姓名 | マツウラ, シン | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 13825 | |||||
| 姓名 | カナヤマ, マサヤ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 13826 | |||||
| 姓名 | ヨシダ, アルト | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12438 | |||||
| 姓名 | イトウ, ケン | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12440 | |||||
| 姓名 | 伊東, 健 | |||||
| 著者所属 | ||||||
| 値 | Department of Stress Response Science, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Central Laboratories for Frontier Technology, Kirin Holdings Co. Ltd. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The long-term function of a graft after transplantation is dependent upon ischemia-reperfusion （I/R） injury, which represents the most important alloantigen-independent damage processes during transplantation. Basic leucine zipper（ b-Zip） transcription factor NF-E2-related factor 2（ Nrf2） is protective against I/R injury by promoting antioxidative and anti-inflammatory mechanisms via up-regulation of antioxidant-responsive element （ARE）-regulated genes such as heme oxygenase 1 and γ-glutamylcysteine ligase. We previously demonstrated that macrophage Nrf2 plays an important role in an elastase-induced acute lung injury model. To further clarify the mechanisms that act downstream of Nrf2, we performed microarray analysis in the RAW264.7 murine macrophage cell line using endogenous electrophilic prostaglandin 15-deoxy-Δ12,14-prostagrandin J2 （15d-PGJ2）. As a result, we identified ferroportin 1 （Fpn1） as a novel Nrf2 target gene. Fpn1 is the sole iron exporter in mammals and regulates iron homeostasis. On the other hand, free intracellular iron is detrimental to cells by enhancing both inflammation and Fenton reaction-mediated oxidative stress. We demonstrated that Nrf2 activation by several electrophilic compounds commonly result in the up-regulation of Fpn1 mRNA in bone marrow-derived and peritoneal macrophages obtained from wild-type, but not from Nrf2 knockout mice. Furthermore, Nrf2 activation enhances iron release from the murine macrophage cell line J774.1. It is previously reported that LPS suppresses Fpn1 mRNA expression, which leads to iron retention in monocytes and macrophages. We showed that while LPS suppress Fpn1 mRNA expression in human macrophages, Nrf2 activation restores the expression of Fpn1. Thus, we propose that iron-metabolism regulation may be an important factor of the Nrf2-mediated cytoprotective mechanism. |
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| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 弘前医学. 64(Suppl.), 2013, p.S74-S80 | |||||
| 書誌情報 |
弘前医学 巻 64, 号 Supplement, p. S74-S80, 発行日 2013-04-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
