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アイテム
Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Fulminant Hepatitis in Mice Induced by Concanavalin A
http://hdl.handle.net/10129/4873
http://hdl.handle.net/10129/4873108e2f9c-ee92-4098-9e57-c3ab7aa6ce5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_64_S90.pdf (313.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2013-04-30 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Fulminant Hepatitis in Mice Induced by Concanavalin A | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | acute liver failure | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | autoimmune hepatitis | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | mesenchymal stem cell | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | cell therapy | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Kubo, Norihito
× Kubo, Norihito
× Narumi, Shunji
× Hakamada, Kenichi
× Nakane, Akio
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| 著者(ヨミ) | ||||||||||||||
| 識別子Scheme | WEKO | |||||||||||||
| 識別子 | 13862 | |||||||||||||
| 姓名 | クボ, ノリヒト | |||||||||||||
| 著者(ヨミ) | ||||||||||||||
| 識別子Scheme | WEKO | |||||||||||||
| 識別子 | 11255 | |||||||||||||
| 姓名 | ナルミ, シュンジ | |||||||||||||
| 著者(ヨミ) | ||||||||||||||
| 識別子Scheme | WEKO | |||||||||||||
| 識別子 | 11312 | |||||||||||||
| 姓名 | ハカマダ, ケンイチ | |||||||||||||
| 著者(ヨミ) | ||||||||||||||
| 識別子Scheme | WEKO | |||||||||||||
| 識別子 | 11501 | |||||||||||||
| 姓名 | ナカネ, アキオ | |||||||||||||
| 著者別名 | ||||||||||||||
| 識別子Scheme | WEKO | |||||||||||||
| 識別子 | 11307 | |||||||||||||
| 識別子Scheme | 研究者総覧 | |||||||||||||
| 識別子URI | http://hue2.jm.hirosaki-u.ac.jp/html/257_ja.html | |||||||||||||
| 識別子 | 257 | |||||||||||||
| 姓名 | 袴田, 健一 | |||||||||||||
| 著者別名 | ||||||||||||||
| 識別子Scheme | WEKO | |||||||||||||
| 識別子 | 11492 | |||||||||||||
| 姓名 | 中根, 明夫 | |||||||||||||
| 著者所属 | ||||||||||||||
| Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Stem cell therapy is one of the remarkable treatments for fatal diseases. Mesenchymal stem cells （MSCs） are adult stem cells and detected in various tissues such as bone marrow, umbilical cord blood and adipose tissue. MSCs have some abilities to differentiate into multi-lineage mature cells, modify immune responses and play a role for tissue repairing. The purpose of the present study was to investigate the effect of adipose tissuederived mesenchymal stem cells（ ASCs） against fulminant hepatitis, a life threatening liver injury due to massive destruction of hepatocytes. BALB/c mice were sacrificed and adipose tissues were harvested. ASCs were purified from the tissues and confirmed by characterization of cell surface markers and induction of differentiation into multi-lineage mature cells. Concanavalin A （ConA）, a protein of jackbean, can induce fulminant hepatitis for mice. BALB/c mice were administered lethal or sublethal dose of ConA intravenously and treated by ASCs, phosphate buffered saline（ PBS） or splenocytes （SPLCs）. The survival rates, liver enzymes, cytokines, histopathological changes and localization of ASCs were investigated. ASCs could increase the survival rates, inhibit elevation of liver enzymes and cytokines, and attenuate necroses of hepatocytes compared to PBS or SPLCs. Fluorescent stained ASCs were detected in inflammatory liver, but not in normal liver. These findings suggest that ASCs have an ability to improve or attenuate fulminant hepatitis. |
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| 引用 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 弘前医学. 64(Suppl.), 2013, p.S90-S98 | |||||||||||||
| 書誌情報 |
弘前医学 巻 64, 号 Supplement, p. S90-S98, 発行日 2013-04-02 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00211444 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 日本十進分類法 | ||||||||||||||
| 主題Scheme | NDC | |||||||||||||
| 主題 | 490 | |||||||||||||
| NIIサブジェクト | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | 医学 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 値 | Article | |||||||||||||
