| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-03-31 |
| タイトル |
|
|
タイトル |
Increases in Plasma Aβ40 Levels and the Aβ40/42 Ratio in Patients with Diabetes Mellitus and Dementia |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Dementia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Diabetes mellitus |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
HbA1c |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Plasma Aβ40 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Plasma Aβ40/42ratio |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ueno, Yaeko
Nagaoka, Motohiro
Nakamura, Takumi
Abe, Naoko
Nakata, Takashi
Wakasaya, Yasuhito
Matsubara, Etsuro
Kawarabayashi, Takeshi
Shoji, Mikio
|
| 著者所属 |
|
|
値 |
Department of Internal Medicine, Ube Kyoritsu Hospital |
| 著者所属 |
|
|
値 |
Department of Psychiatry, Ube Kyoritsu Hospital |
| 著者所属 |
|
|
値 |
Department of Neurology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Neurology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Neurology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Neurology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Neurology, Oita University Faculty of Medicine |
| 著者所属 |
|
|
値 |
Department of Neurology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Neurology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: The plasma Aβ40/42 ratio is a possible biomarker for the onset of Alzheimer’s disease （AD）. We here measured plasma Aβ40 and Aß42 levels in patients with diabetes mellitus （DM） and dementia in order to clarify the relationship between DM and AD. Methods: Fifty-three patients, including 33 patients with DM and 25 patients with dementia, were assessed using the Mini-mental state examination （MMSE） and brain MRI, plasma Aβ40 and Aβ42, blood sugar levels, and HbA1c % were measured, and the genotype of apolipoprotein E was determined. Plasma Aβ levels and blood sugar levels were measured in 16 out of 53 patients, following fasting and 2 hours after breakfast. Results: Plasma Aβ40 levels and the Aβ40/42 ratio were increased in the DM with dementia group （p<0.01, p<0.001）, while HbA1c % correlated with the Aβ40/42 ratio in the non-dementia group. MMSE scores were also associated with the plasma Aβ40/42 ratio and Aβ40 levels in the non-dementia group, independent of the presence of ApoEε4. We did not observed significant direct responses of plasma Aβ protains to an increase in blood sugar levels. Conclusion: These results suggest that plasma Aβ metabolism are closely related chronic hyperglycemia before the onset of dementia. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 66, 2016, p.110-119 |
| 書誌情報 |
弘前医学
巻 66,
号 2-4,
p. 110-119,
発行日 2016-03-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_66(2-4)_110.pdf (1.1 MB)
