| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-03-31 |
| タイトル |
|
|
タイトル |
Desferrioxamine, An Iron Chelator, Induces CXCL8 Expression in U373MG Human Astrocytoma Cells |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
desferrioxamine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CXCL8 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
U373MG cells |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
iron |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
VEGF |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Onda, Kaoru
Yoshida, Hidemi
Hayakari, Ryo
Xing, Fei
Wang, Lian
Matsumiya, Tomoh
Kawaguchi, Shogo
Murakami, Manabu
Imaizumi, Tadaatsu
|
| 著者所属 |
|
|
|
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Gastroenterology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Pharmacology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Dysregulation of iron homeostasis in brain causes various neurodegenerative disorders. In fact, high concentration of iron is present in brains of patients with Alzheimer’s disease. It was previously reported that CXCL8 protects human neurons from amyloid-β-induced neurotoxicity and that astrocytes have the potential to play important roles in Alzheimer’s disease. In the present study, we examined the effect of desferrioxamine, an iron chelator, on the expression of CXCL8 in U373MG human astrocytoma cells used as a model of astrocytes. Treatment of the cells with desferrioxamine induced the expression of CXCL8. Pretreatment of the cells with FeSO4 counteracted the positive effect of desferrioxamine on CXCL8 production, suggesting that the effect of desferrioxamine was due to iron chelation. RNA interference experiments showed that HIF-1α was not involved in desferrioxamine-induced CXCL8 expression. We conclude that desferrioxamine induces CXCL8 in astrocytes and the chelation of iron may be a new therapeutic strategy for Alzheimer’s disease. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 66, 2016, p.127-134 |
| 書誌情報 |
弘前医学
巻 66,
号 2-4,
p. 127-134,
発行日 2016-03-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_66(2-4)_127.pdf (666.6 kB)
