| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-03-31 |
| タイトル |
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|
タイトル |
Clock Gene Expressions are Altered by Co-culture of Gingival Fibroblasts and Oral Cancer Cells |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
clock genes |
| キーワード |
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主題Scheme |
Other |
|
主題 |
oral cancer cells |
| キーワード |
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主題Scheme |
Other |
|
主題 |
fibroblasts |
| キーワード |
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主題Scheme |
Other |
|
主題 |
co-culture |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Furudate, Ken
Matsumiya, Tomoh
Hayakari, Ryo
Xing, Fei
Kubota, Kosei
Sakaki, Hirotaka
Tamura, Yoshihiro
Kijima, Hiroshi
Imaizumi, Tadaatsu
Kimura, Hiroto
Kobayashi, Wataru
|
| 著者所属 |
|
|
|
Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Tumor microenvironment is related to growth, survival, invasion, and metastasis of tumor cells. Several studies have proved that stromal fibroblasts play an important role in the tumor microenvironment to convert cancer-associated fibroblast （CAFs）. Clock genes are known to regulate circadian rhythms, angiogenesis, and immunoreaction. In addition, clock genes play an important role in cancer development. However, little has been shown about how these clock genes function in the tumor microenvironment. In the present study, we investigated to evaluate the effect of co-culture fibroblasts with oral cancer cells on the expression of clock genes. Following the coculture of human primary fibroblasts with human gingival carcinoma Ca9-22 cells, the expression levels of clock genes were analyzed by real-time quantitative PCR. We found that the rhythmic expression of clock genes were altered, enhanced, or disappeared by the co-culture. Such effect was observed not only in fibroblasts in the presence of Ca9-22 cells but also in Ca9-22 cells in the presence of fibroblasts. Our results suggested that clock genes might affect an important role in the tumor microenvironment. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 66, 2016, p.135-142 |
| 書誌情報 |
弘前医学
巻 66,
号 2-4,
p. 135-142,
発行日 2016-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
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主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_66(2-4)_135.pdf (712.6 kB)
