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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 66巻2-4号

Clock Gene Expressions are Altered by Co-culture of Gingival Fibroblasts and Oral Cancer Cells

http://hdl.handle.net/10129/5809
http://hdl.handle.net/10129/5809
04ecd3a1-f3ed-4f31-a6d8-a3fa2fe75894
名前 / ファイル ライセンス アクション
HirosakiMedJ_66(2-4)_135.pdf HirosakiMedJ_66(2-4)_135.pdf (712.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-03-31
タイトル
タイトル Clock Gene Expressions are Altered by Co-culture of Gingival Fibroblasts and Oral Cancer Cells
言語
言語 eng
キーワード
主題Scheme Other
主題 clock genes
キーワード
主題Scheme Other
主題 oral cancer cells
キーワード
主題Scheme Other
主題 fibroblasts
キーワード
主題Scheme Other
主題 co-culture
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Furudate, Ken

× Furudate, Ken

Furudate, Ken

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Matsumiya, Tomoh

× Matsumiya, Tomoh

Matsumiya, Tomoh

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Hayakari, Ryo

× Hayakari, Ryo

Hayakari, Ryo

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Xing, Fei

× Xing, Fei

Xing, Fei

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Kubota, Kosei

× Kubota, Kosei

Kubota, Kosei

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Sakaki, Hirotaka

× Sakaki, Hirotaka

Sakaki, Hirotaka

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Tamura, Yoshihiro

× Tamura, Yoshihiro

Tamura, Yoshihiro

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Kijima, Hiroshi

× Kijima, Hiroshi

Kijima, Hiroshi

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Imaizumi, Tadaatsu

× Imaizumi, Tadaatsu

Imaizumi, Tadaatsu

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Kimura, Hiroto

× Kimura, Hiroto

Kimura, Hiroto

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Kobayashi, Wataru

× Kobayashi, Wataru

Kobayashi, Wataru

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著者所属
値 Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 Tumor microenvironment is related to growth, survival, invasion, and metastasis of tumor cells. Several studies have proved that stromal fibroblasts play an important role in the tumor microenvironment to convert cancer-associated fibroblast (CAFs). Clock genes are known to regulate circadian rhythms, angiogenesis, and immunoreaction. In addition, clock genes play an important role in cancer development. However, little has been shown about how these clock genes function in the tumor microenvironment. In the present study, we investigated to evaluate the effect of co-culture fibroblasts with oral cancer cells on the expression of clock genes. Following the coculture of human primary fibroblasts with human gingival carcinoma Ca9-22 cells, the expression levels of clock genes were analyzed by real-time quantitative PCR. We found that the rhythmic expression of clock genes were altered, enhanced, or disappeared by the co-culture. Such effect was observed not only in fibroblasts in the presence of Ca9-22 cells but also in Ca9-22 cells in the presence of fibroblasts. Our results suggested that clock genes might affect an important role in the tumor microenvironment.
引用
内容記述タイプ Other
内容記述 弘前医学. 66, 2016, p.135-142
書誌情報 弘前医学

巻 66, 号 2-4, p. 135-142, 発行日 2016-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
日本十進分類法
主題Scheme NDC
主題 490
NIIサブジェクト
主題Scheme Other
主題 医学
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
資源タイプ
値 Article
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