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Clinical Utility of Skin Biopsy in Differentiating between Parkinson’s Disease and Multiple System Atrophy
http://hdl.handle.net/10129/5667
http://hdl.handle.net/10129/5667033c02f7-f6fb-44db-a7c0-4be78b22b05c
| 名前 / ファイル | ライセンス | アクション |
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本文 (1.0 MB)
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審査要旨 (123.5 kB)
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内容要旨 (178.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2015-10-27 | |||||||
| タイトル | ||||||||
| タイトル | Clinical Utility of Skin Biopsy in Differentiating between Parkinson’s Disease and Multiple System Atrophy | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
Haga, Rie
× Haga, Rie
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| 著者(ヨミ) | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 16039 | |||||||
| 姓名 | ハガ, リエ | |||||||
| 著者別名 | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 16040 | |||||||
| 姓名 | 羽賀, 理恵 | |||||||
| 著者所属 | ||||||||
| 弘前大学大学院医学研究科 | ||||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background. It is often difficult to differentiate Parkinson’s disease (PD) from multiple system atrophy (MSA), especially in their early stages. Objectives. To examine the clinical utility of histopathological analysis of biopsied skin from the chest wall and/or leg in differentiating between the two diseases. Methods. Skin biopsies from the lower leg and/or anterior chest wall were obtained from 38 patients with idiopathic PD (26 treated with levodopa and 12 levodopa-na¨ıve) and 13 age-matched patients with MSA.We sought aggregates of phosphorylated α-synuclein on cutaneous nerve fibers using double fluorescence immunohistochemistry and confocal microscopy and measured intraepidermal nerve fiber density (IENFD). Results. Phosphorylated α-synuclein aggregates were identified on cutaneous nerves in two patients with PD (5.3%) but in none of the patients with MSA, and IENFD was significantly lower in patients with PD when compared to those with MSA.There was no difference in IENFD between levodopatreated and levodopa-na¨ıve patients with PD. Conclusions.Our findings suggest that an assessment of IENFD in biopsied skin could be a useful means of differentiating between PD and MSA but that detection of α-synuclein aggregates on cutaneous nerves in the distal sites of the body is insufficiently sensitive. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Parkinson’s Disease Volume 2015 (2015), Article ID 167038, 7 pages http://dx.doi.org/10.1155/2015/167038 |
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| 書誌情報 | p. 1-17, 発行日 2015-09-30 | |||||||
| 日本十進分類法 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 493.74 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | ETD | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | パーキンソン病と多系統萎縮症の鑑別における皮膚生検の有用性 | |||||||
| タイトル（ヨミ） | ||||||||
| その他のタイトル | パーキンソンビョウ ト タケイトウ イシュクショウ ノ カンベツ ニオケル ヒフ セイケン ノ ユウヨウセイ | |||||||
| NIIサブジェクト | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 基礎医学 | |||||||
| 資源タイプ | ||||||||
| 値 | Thesis | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関名 | 弘前大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2015-09-30 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲1906 | |||||||
