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Inflammatory chemokine expression via Toll-like receptor 3 signaling in normal human mesangial cells.
http://hdl.handle.net/10129/00006506
http://hdl.handle.net/10129/00006506bf150e87-484e-48d8-aafe-61c0db3f9d50
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Clin Dev Immunol_2.pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2019-02-22 | |||||||||
| タイトル | ||||||||||
| タイトル | Inflammatory chemokine expression via Toll-like receptor 3 signaling in normal human mesangial cells. | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Tanaka, Hiroshi
× Tanaka, Hiroshi
× Imaizumi, Tadaatsu
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The innate and adaptive immune systems have been reported to play an important role in the pathogenesis of glomerular diseases. Since viral infections may trigger the development of inflammatory renal disease or the worsening of preexisting renal disease, recent studies have focused on the involvement of toll-like receptors (TLRs) and their signaling pathways in the inflammatory processes of glomerular cells. Viral double-stranded RNA (dsRNA) can activate not only TLR3 located within intracellular endosomes but also retinoic-acid-inducible-gene-I- (RIG-I-) like helicase receptors located within the cytosol. RIG-I and melanoma differentiation-associated gene 5 (MDA5) are members of the RNA helicase family in the cytosol, and both act as pathogen recognition receptors. The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and noninfectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. However, there are few data on the interaction between TLR3, MDA5, and RIG-I in autoimmune glomerular diseases. Based on our recent experimental studies using cultured normal human mesangial cells (MCs), we found that novel TLR3-mediated signaling pathways in MCs may be involved in the pathogenesis of glomerular diseases. In the present paper, we summarize our recent findings. | |||||||||
| 書誌情報 |
Clinical & developmental immunology 巻 2013, p. 984708, 発行日 2013 |
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| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1740-2522 | |||||||||
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| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11862023 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 23935652 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1155/2013/984708 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 資源タイプ | ||||||||||
| 値 | Article | |||||||||
