| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-02-22 |
| タイトル |
|
|
タイトル |
Urinary fractalkine and monocyte chemoattractant protein-1 as possible predictors of disease activity of childhood glomerulonephritis. |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Adolescent |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Biopsy |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Chemokine CCL2 |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chemokine CX3CL1 |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Chemokines |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Child |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Child, Preschool |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Creatinine |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Female |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gene Expression Regulation |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Glomerulonephritis |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Glomerulonephritis, IGA |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glomerulonephritis, Membranous |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Humans |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Inflammation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Kidney |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lupus Nephritis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Male |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Aizawa, Tomomi
Imaizumi, Tadaatsu
Tsuruga, Kazushi
Watanabe, Shojiro
Yoshida, Hidemi
Kumagai, Naonori
Ito, Etsuro
Tanaka, Hiroshi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Renal biopsy is the gold standard for confirmation of disease severity and diagnosis of glomerulonephritis (GN), but its procedure is invasive with a risk of complications. Thus, a non-invasive monitoring method is desirable especially in pediatric patients. Fractalkine and monocyte chemoattractant protein-1 (MCP-1) are proinflammatory chemokines, and both have been reported to be involved in the pathogenesis of immunocomplex-mediated GN. Recently, it has been reported that urinary fractalkine and MCP-1 may serve as possible predictors of disease activity of adult patients with GN. We, therefore, examined whether urinary levels of fractalkine and MCP-1 correlate with clinical and histologic parameters. Twenty-six consecutive children with various types of GN were enrolled in this study, including lupus nephritis, IgA nephropathy, membranous nephropathy, acute GN, and thin basement membrane disease (served as a non-inflammatory control). Urinary fractalkine and MCP-1 concentrations in the first morning urine samples obtained at the time of renal biopsy were measured by enzyme-linked immunosorbent assay, and standardized for urinary creatinine concentrations. Urinary fractalkine concentration differed significantly among the disease categories. Urinary concentrations of fractalkine and MCP-1 showed a significant positive correlation with the degree of occult blood in urine and a significant inverse correlation with the estimated glomerular filtration rate. Furthermore, the urinary MCP-1 concentration was significantly correlated with histological chronicity indices in patients with lupus nephritis and IgA nephropathy. Measurement of urinary fractalkine and MCP-1 concentrations may be useful as a non-invasive method for predicting the disease activity of GN in children. |
| 書誌情報 |
en : The Tohoku journal of experimental medicine
巻 231,
号 4,
p. 265-270,
発行日 2013-12
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-3329 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00863920 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
PMID |
|
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関連識別子 |
24284376 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
|
|
値 |
Article |
Urinary Fkn and MCP-1 (TJEM)_4.pdf (447.2 kB)
