| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-05 |
| タイトル |
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|
タイトル |
Ascorbic acid does not reduce the anticancer effect of radiotherapy |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hosokawa, Yoichiro
Saga, Ryo
Monzen, Satoru
Terashima, Shingo
Tsuruga, Eichi
|
| 著者所属 |
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|
値 |
Hirosaki Univ, Dept Radiat Sci, Grad Sch Hlth Sci |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The present study hypothesized that the therapeutic use of ascorbic acid (AsA) in combination with radiation may reduce therapy-related side effects and increase the antitumor effects. The aim of the study was to examine the association between the scavenged activity of AsA and the biological anticancer effect of hydroxyl (OH) radicals generated by X-ray irradiation. Cell survival, DNA fragmentation of human leukemia HL60 cells and the amount of OH radicals were investigated following X-ray irradiation and AsA treatment. The number of living cells decreased, and DNA fragmentation increased at AsA concentrations >1 mM. Electron spin resonance spectra revealed that X-ray irradiation generated OH radicals, which were scavenged by AsA at concentrations >75 mu M. The AsA concentration inside the cell was 75 mu M when cells underwent extracellular treatment with 5 mM AsA, which significantly induced HL60 cell death even without irradiation. No increase in the number of viable HL60 cells was observed following AsA treatment with irradiation when compared to irradiation alone. In conclusion, the disappearance of the radiation anticancer effects with AsA treatment in combination with radiotherapy for cancer treatment is not a cause for concern. |
| 書誌情報 |
BIOMEDICAL REPORTS
巻 6,
号 1,
p. 103-107,
発行日 2017-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2049-9434 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.3892/br.2016.819 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
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|
値 |
Article |
ptpmcrender.fcgi (375.1 kB)
