| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-07 |
| タイトル |
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タイトル |
Association between serum prolactin levels and insulin resistance in non-diabetic men |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Daimon, Makoto
Kamba, Aya
Murakami, Hiroshi
Mizushiri, Satoru
Osonoi, Sho
Yamaichi, Masato
Matsuki, Kota
Sato, Eri
Tanabe, Jutaro
Takayasu, Shinobu
Matsuhashi, Yuki
Yanagimachi, Miyuki
Terui, Ken
Kageyama, Kazunori
Tokuda, Itoyo
Takahashi, Ippei
Nakaji, Shigeyuki
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| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
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Hirosaki Univ, Grad Sch Med, Dept Social Med |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Social Med |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Social Med |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Prolactin (PRL) has roles in various physiological functions. Although experimental studies showed that PRL has both beneficial and adverse effects on type 2 diabetes mellitus, clinical findings in subjects with hyperprolactinemia indicate adverse effects on glucose metabolism. However, effects of PRL within the physiological range in human are controversial. A population-based study of 370 Japanese men enrolled in the 2014 Iwaki study (aged 52.0 +/- 14.8 years). In this cross-sectional study, associations between serum PRL levels and homeostatic model assessment (HOMA) indices representing glucose metabolism in a physiological setting were examined using multivariable regression analysis. Although univariate linear regression analyses showed significant associations between serum PRL levels and HOMA indices, adjustment with multiple factors made the association with HOMA-beta (insulin secretion) insignificant, while those with HOMA-R (insulin resistance) remained significant (beta = 0.084, p = 0.035). Non-linear regression analyses showed a regression curve with a peak at serum PRL level, 12.4 ng/mL and a positive association of serum PRL level with HOMA-R below the peak (beta = 0.119, p = 0.004). Higher serum PRL levels within the physiological range seem to be associated with insulin resistance in men. |
| 書誌情報 |
PLOS ONE
巻 12,
号 4,
p. e0175204,
発行日 2017-04-06
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1932-6203 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pone.0175204 |
| 資源タイプ |
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値 |
Article |
Plos_one (861.4 kB)
