| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-07 |
| タイトル |
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タイトル |
Dominance of the hypothalamus-pituitary-adrenal axis over the renin-angiotensin-aldosterone system is a risk factor for decreased insulin secretion |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Daimon, Makoto
Kamba, Aya
Murakami, Hiroshi
Mizushiri, Satoru
Osonoi, Sho
Matsuki, Kota
Sato, Eri
Tanabe, Jutaro
Takayasu, Shinobu
Matsuhashi, Yuki
Yanagimachi, Miyuki
Terui, Ken
Kageyama, Kazunori
Tokuda, Itoyo
Kurauchi, Shizuka
Nakaji, Shigeyuki
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| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Endocrinol & Metab |
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Hirosaki Univ, Grad Sch Med, Dept Social Med |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Social Med |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Social Med |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
How the association between the hypothalamus-pituitary-adrenal (HPA) axis and the reninangiotensin-aldosterone system (RAAS) affects glucose metabolism were not well examined in a general population. Participants of the population-based 2015 Iwaki study were enrolled (n: 1,016; age: 54.4 +/- 15.1 years). Principal component (PC) analysis identified two PCs: PC1 represented levels of the HPA axis (serum cortisol) and the RAAS (plasma aldosterone) as a whole, and PC2 represented the HPA axis relative to the RAAS (HPA axis dominance). We examined the association between these PCs and glucose metabolism using homeostasis model assessment indices of reduced insulin sensitivity (HOMA-R) and secretion (HOMA-beta). Univariate linear regression analyses showed a correlation between PC2 and HOMA-beta (beta = -0.248, p < 0.0001), but not between PC1 and HOMA-beta (beta = -0.004, p = 0.9048). The correration between PC2 and HOMA-beta persisted after adjustment for multiple factors (beta = -0.101, p = 0.0003). No correlations were found between the PCs and HOMA-R. When subjects were tertiled based on PC2, the highest tertile was at greater risk of decreased insulin secretion (defined as the lower one third of HOMA-beta (<= 68.9)) than the lowest tertile after adjustment for multiple factors (odds ratio, 2.00; 95% confidence interval, 1.35-2.97). The HPA axis dominance is associated with decreased insulin secretion in a Japanese population. |
| 書誌情報 |
SCIENTIFIC REPORTS
巻 7,
p. 11360,
発行日 2017-09-12
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-017-10815-y |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
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値 |
Article |
s41598-017-10815-y (1.7 MB)
