| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-08 |
| タイトル |
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タイトル |
Prognostic Impact of Extracapsular Lymph Node Invasion and Myofibroblastic Activity in Extrahepatic Bile Duct Cancer |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yoshizawa, Tadashi
Ishido, Keinosuke
Saitou, Kensuke
Haga, Toshihiro
Seino, Hiroko
Wu, Yunyan
Morohashi, Satoko
Hakamada, Kenichi
Kijima, Hiroshi
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| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Gastroenterol Surg |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Gastroenterol Surg |
| 著者所属 |
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Hirosaki Univ, Grad Sch Med, Dept Pathol & Biosci |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Extrahepatic bile duct carcinoma is a potentially malignant gastrointestinal lesion. Cancer cells spread via the lymphatic system to regional lymph nodes and help in tumor progression. However, there are no reports on the prognostic impact of extracapsular lymph node invasion and myofibroblastic activity in this cancer. Hence, we classified the histopathologic patterns of lymph nodes into 2 patterns: extracapsular lymph node invasion or not. Based on this, we investigated 32 cases of extrahepatic bile duct cancer with lymph node metastasis and classified 21 cases as positive and 11 cases as negative. The extracapsular lymph node invasion cases were associated with poor disease-free survival and overall survival. The myofibroblast density of the metastatic foci was significantly higher in the extracapsular lymph node invasion cases. This is the first study to demonstrate that extracapsular lymph node invasion cases were associated with poor prognosis and that the myofibroblast distribution contributed to malignancy. |
| 書誌情報 |
CLINICAL MEDICINE INSIGHTS- PATHOLOGY
巻 10,
p. UNSP 1179555717729652,
発行日 2017-09-06
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1179-5557 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1177/1179555717729652 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
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値 |
Article |
1179555717729652 (963.4 kB)
