| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-08 |
| タイトル |
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タイトル |
Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hamano, Itsuto
Hatakeyama, Shingo
Iwamura, Hiromichi
Fujita, Naoki
Fukushi, Ken
Narita, Takuma
Hagiwara, kazuhisa
Kusaka, Ayumu
Hosogoe, Shogo
Yamamoto, Hayato
Tobisawa, Yuki
Yoneyama, Tohru
Yoneyama, Takahiro
Hashimoto, Yasuhiro
Koie, Takuya
Ito, Hiroyuki
Yoshikawa, Kazuaki
Kawaguchi, Toshiaki
Ohyama, Chikara
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| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Adv Transplant & Regenerat Med |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Adv Transplant & Regenerat Med |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 著者所属 |
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値 |
Aomori Rosai Hosp, Dept Urol |
| 著者所属 |
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値 |
Mutsu Gen Hosp, Dept Urol |
| 著者所属 |
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値 |
Aomori Prefectural Cent Hosp |
| 著者所属 |
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値 |
Hirosaki Univ, Grad Sch Med, Dept Urol |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy.
Methods: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-free, cancer-specific, and overall survival (PFS, CSS, and OS, respectively) stratified by preoperative CKD status (pre-CKD vs. non-CKD). We performed a Cox proportional hazards regression analysis using inverse probability of treatment weighting (IPTW) to evaluate the impact of preoperative CKD on prognosis and developed the prognostic factor-based risk stratification nomogram.
Results: Of the 581 patients, 215 (37%) were diagnosed with CKD before radical cystectomy. Before the background adjustment, PFS, CSS, and OS after radical cystectomy were significantly lower in the pre-CKD group compared to the non-CKD group. Background-adjusted IPTW analysis showed that preoperative CKD was significantly associated with poor PFS, CSS, and OS after radical cystectomy. The nomogram for predicting 5-year PFS and OS probability showed significant correlation with actual PFS and OS (c-index = 0.73 and 0.77, respectively).
Conclusions: Muscle-invasive bladder cancer patients with preoperative CKD had a significantly lower survival probability than those without CKD. |
| 書誌情報 |
ONCOTARGET
巻 8,
号 37,
p. 61404-61414,
発行日 2017-09-05
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1949-2553 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.18632/oncotarget.18248 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
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値 |
Article |
oncotarget-61404 (2.6 MB)
