| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-11 |
| タイトル |
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タイトル |
The influence of serum uric acid on renal function in patients with calcium or uric acid stone: A population-based analysis |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Tanaka, Yoshimi
Hatakeyama, Shingo
Tanaka, Toshikazu
Yamamoto, Hayato
Narita, Takuma
Hamano, Itsuto
Matsumoto, Teppei
Soma, Osamu
Okamoto, Teppei
Tobisawa, Yuki
Yoneyama, Tohru
Yoneyama, Takahiro
Hashimoto, Yasuhiro
Koie, Takuya
Takahashi, Ippei
Nakaji, Shigeyuki
Terayama, Yuriko
Funyu, Tomihisa
Ohyama, Chikara
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| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
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Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
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Hirosaki Univ, Dept Social Med, Sch Med |
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Hirosaki Univ, Dept Social Med, Sch Med |
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Oyokyo Kidney Res Inst, Dept Urol |
| 著者所属 |
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Oyokyo Kidney Res Inst, Dept Urol |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objectives
To determine the influence of serum uric acid (UA) levels on renal impairment in patients with UA stone.
Materials and methods
We retrospectively analyzed 463 patients with calcium oxalate and/or calcium phosphate stones (CaOx/CaP), and 139 patients with UA stones. The subjects were divided into the serum UA-high (UA > 7.0 mg/dL) or the UA-low group (UA < 7.0 mg/dL). The control group comprised 3082 community-dwelling individuals that were pair-matched according to age, sex, body mass index, comorbidities, hemoglobin, serum albumin, and serum UA using propensity score matching. We compared renal function between controls and patients with UA stone (analysis 1), and between patients with CaOx/CaP and with UA stone (analysis 2). Logistic regression analysis was used to evaluate the impact of the hyperuricemia on the development of stage 3 and 3B chronic kidney disease (CKD) (analysis 3).
Results
The renal function was significantly associated with serum UA levels in the controls and patients with CaOx/CaP and UA stones. In pair-matched subgroups, patients with UA stone had significantly lower renal function than the control subjects (analysis 1) and patients with CaOx/CaP stones (analysis 2) regardless of hyperuricemia. Multivariate logistic regression analysis revealed that patients with UA stone, CaOx/CaP, hyperuricemia, presence of cardiovascular disease, higher body mass index, older age and lower hemoglobin had significantly higher risk of stage 3 and 3B CKD (analysis 3).
Conclusion
Patients with UA stones had significantly worse renal function than controls and CaOx/CaP patients regardless of hyperuricemia. Urolithiasis (CaOx/CaP and UA stone) and hyperuricemia had an association with impaired renal function. Our findings encourage clinicians to initiate intensive treatment and education approaches in patients with urolithiasis and/or hyperuricemia in order to prevent the progression of renal impairment. |
| 書誌情報 |
PLOS ONE
巻 12,
号 7,
p. e0182136,
発行日 2017-07-31
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1932-6203 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pone.0182136 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
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値 |
Article |
Plos_One (2.3 MB)
