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  1. 30 医学部・医学研究科・保健学研究科
  2. 30a 学術雑誌論文
  3. 1.学術雑誌論文

Impact of time interval and dose rate on cell survival following low-dose fractionated exposures.

http://hdl.handle.net/10129/00006812
http://hdl.handle.net/10129/00006812
c2966919-b5b4-4998-8533-921253c9a421
名前 / ファイル ライセンス アクション
rrx025.pdf rrx025.pdf (712.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-20
タイトル
タイトル Impact of time interval and dose rate on cell survival following low-dose fractionated exposures.
言語
言語 eng
キーワード
主題Scheme Other
主題 low dose hyper-radiosensitivity
キーワード
主題Scheme Other
主題 dose rate
キーワード
主題Scheme Other
主題 time interval
キーワード
主題Scheme Other
主題 low-dose fractionated exposure
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Terashima, Shingo

× Terashima, Shingo

Terashima, Shingo

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Hosokawa, Yoichiro

× Hosokawa, Yoichiro

Hosokawa, Yoichiro

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Tsuruga, Eichi

× Tsuruga, Eichi

Tsuruga, Eichi

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Mariya, Yasushi

× Mariya, Yasushi

Mariya, Yasushi

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Nakamura, Toshiya

× Nakamura, Toshiya

Nakamura, Toshiya

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著者所属
値 Department of Radiation Science, Hirosaki University Graduate School of Health Sciences
著者所属
値 Department of Radiation Science, Hirosaki University Graduate School of Health Sciences
著者所属
値 Department of Radiation Science, Hirosaki University Graduate School of Health Sciences
著者所属
値 Department of Radiology, Mutsu General Hospital
著者所属
値 Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences
抄録
内容記述タイプ Abstract
内容記述 Enhanced cell lethality, also known as hyper-radiosensitivity, has been reported at low doses of radiation (≤0.5 Gy) in various cell lines, and is expected to be an effective cancer therapy. We conducted this study to examine the impact of time interval and dose rate of low-dose fractionated exposures with a short time interval. We evaluated the cell-survival rates of V79 and A549 cells using clonogenic assays. We performed fractionated exposures in unit doses of 0.25, 0.5, 1.0 and 2.0 Gy. We exposed the cells to 2 Gy of X-rays (i) at dose-rates of 1.0, 1.5 and 2.0 Gy/min at 1-min intervals and (ii) at a dose-rate of 2.0 Gy/min at 10-s, 1-min and 3-min intervals by fractionated exposures. Apoptosis and cell cycle analyses were also evaluated in the fractionated exposures (unit dose 0.25 Gy) and compared with single exposures by using flow cytometry. Both cell-type survival rates with fractionated exposures (unit dose 0.25 Gy) with short time intervals were markedly lower than those for single exposures delivering the same dose. When the dose rates were lower, the cytotoxic effect decreased compared with exposure to a dose-rate of 2.0 Gy/min. On the other hand, levels of apoptosis and cell cycle distribution were not significantly different between low-dose fractionated exposures and single exposures in either cell line. These results indicate that a stronger cytotoxic effect was induced with low-dose fractionated exposures with a short time interval for a given dose due to the hyper-radiosensitivity phenomenon, suggesting that dose rates are important for effective low-dose fractionated exposures.© The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology
書誌情報 Journal of Radiation Research

巻 58, 号 6, p. 782-790, 発行日 2017-11
ISSN
収録物識別子タイプ ISSN
収録物識別子 0449-3060
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00705792
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 28595296
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1093/jrr/rrx025
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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