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Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat
http://hdl.handle.net/10129/00007245
http://hdl.handle.net/10129/0000724511231559-4319-4c7f-87b6-c7ef2ba0c56a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hirosaki Med J 71-2-4_101 (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-10 | |||||
| タイトル | ||||||
| タイトル | Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aortic valve stenosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aortic valve calcification | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | local medical therapy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yu, Zaiqiang
× Yu, Zaiqiang× Liu, Xu× Daitoku, Kazuyuki× Furukawa, Ken-Ichi× Fukuda, Ikuo× Motomura, Shigeru× Seya, Kazuhiko |
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| 著者所属 | ||||||
| 値 | Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Pharmacology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Vascular Biology, Hirosaki University Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Aortic valve stenosis （AVS） is the most common heart valve disease in elderly society. The effective treatment for AVS is surgical aortic valve replacement but with extremely invasive. Although transcatheter aortic valvereplacement also is performed for highly risk patients with minimally invasive, it has to resolve the problem ofbioprosthetic valve durability in future. However, there is no effective medical treatment established for AVS toinhibit acceleration of aortic valve calcification. Objectives We aimed to confirm whether the ascending aorta is the best location for AVS to innovate local and selective medicaltherapy or not. Methods and Results After anesthetized by isoflurane, the wild type rat was stablished on operating table. Opening chest to heart bymedian sternotomy approach, the catheter was inserted into left ventricular from apical for body perfusion. Weinjected saturated solution of amido black 10B （AB） into ascending aorta above sino-tubular junction about 0.5 cmfrom aortic valves without aortic dissection observed, and body perfusion was performed by saline containing heparinin order to prevent embolism happened in vascular. After 30 minutes, the heart with the ascending aorta wasextracted. We used optical microscope to check the existence of AB at around of aortic valves or not. Interestingly,AB was detected at around of aortic valves and valsalva sinus of the aorta and myocardium in all rats. Conclusions These results suggested that AB injected is delivered from the ascending aorta to aortic valves through vasavasorum. These data provide very important evidences for local medical therapy development for AVS patients. |
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| 書誌情報 |
弘前医学 巻 71, 号 2-4, p. 101-107, 発行日 2021-03-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
