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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 71巻2-4号

Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat

http://hdl.handle.net/10129/00007245
http://hdl.handle.net/10129/00007245
11231559-4319-4c7f-87b6-c7ef2ba0c56a
名前 / ファイル ライセンス アクション
Hirosaki Hirosaki Med J 71-2-4_101 (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-03-10
タイトル
タイトル Preliminary study on local medical treatment of aortic valve calcification: Drug delivery to aortic valve in rat
言語
言語 eng
キーワード
主題Scheme Other
主題 aortic valve stenosis
キーワード
主題Scheme Other
主題 aortic valve calcification
キーワード
主題Scheme Other
主題 local medical therapy
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Yu, Zaiqiang

× Yu, Zaiqiang

Yu, Zaiqiang

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Liu, Xu

× Liu, Xu

Liu, Xu

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Daitoku, Kazuyuki

× Daitoku, Kazuyuki

Daitoku, Kazuyuki

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Furukawa, Ken-Ichi

× Furukawa, Ken-Ichi

Furukawa, Ken-Ichi

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Fukuda, Ikuo

× Fukuda, Ikuo

Fukuda, Ikuo

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Motomura, Shigeru

× Motomura, Shigeru

Motomura, Shigeru

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Seya, Kazuhiko

× Seya, Kazuhiko

Seya, Kazuhiko

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著者所属
値 Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Pharmacology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 Background
Aortic valve stenosis (AVS) is the most common heart valve disease in elderly society. The effective treatment for AVS is surgical aortic valve replacement but with extremely invasive. Although transcatheter aortic valvereplacement also is performed for highly risk patients with minimally invasive, it has to resolve the problem ofbioprosthetic valve durability in future. However, there is no effective medical treatment established for AVS toinhibit acceleration of aortic valve calcification.
Objectives
We aimed to confirm whether the ascending aorta is the best location for AVS to innovate local and selective medicaltherapy or not.
Methods and Results
After anesthetized by isoflurane, the wild type rat was stablished on operating table. Opening chest to heart bymedian sternotomy approach, the catheter was inserted into left ventricular from apical for body perfusion. Weinjected saturated solution of amido black 10B (AB) into ascending aorta above sino-tubular junction about 0.5 cmfrom aortic valves without aortic dissection observed, and body perfusion was performed by saline containing heparinin order to prevent embolism happened in vascular. After 30 minutes, the heart with the ascending aorta wasextracted. We used optical microscope to check the existence of AB at around of aortic valves or not. Interestingly,AB was detected at around of aortic valves and valsalva sinus of the aorta and myocardium in all rats.
Conclusions
These results suggested that AB injected is delivered from the ascending aorta to aortic valves through vasavasorum. These data provide very important evidences for local medical therapy development for AVS patients.
書誌情報 弘前医学

巻 71, 号 2-4, p. 101-107, 発行日 2021-03-05
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 弘前大学大学院医学研究科
資源タイプ
値 Article
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