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We reported\nthat amiodarone suppresses both electrical and structural remodeling in a canine persistent atrial fi brillation model.\nAs a mechanism for amiodarone’s effect on structural remodeling, we suggested its inhibitory effect on matrix\nmetalloproteinase( MMP) activity. To elucidate it, we investigated the eff ect of amiodarone on MMP activity in a rat\nmyocardial infarction model created by left coronary artery( LCA) ligation. Adult Sprague-Dawley rats were divided\ninto sham-operated (Sham), sham-operated with amiodarone (Sham+AMD), LCA-ligated without amiodarone (MI)\nand LCA-ligated with amiodarone rats (MI+AMD). Amiodarone (20 mg/kg/day) was administered for 2 weeks\nbefore and for 4 weeks after operation. The hearts were excised at 4 weeks after operation. MMP-2 activity was\nmeasured by gelatin zymography. At 4 weeks after surgery, left ventricular fractional shortening was decreased in\nMI but not in MI+AMD rats. There was no diff erence in the infarct size between MI and MI+AMD rats (P=NS).\nAs compared with Sham, MMP-2 activity was increased in MI (P\u003c0.01), but not in MI+AMD (P=NS versus Sham;\nP\u003c0.05 versus MI). MMP-2 activity was not increased in Sham+AMD( P=NS). Thus, amiodarone exerts an inhibitory\neff ect on MMP activity. 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"Other"}, {"subitem_subject": "構造的モデリング", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アミオダロン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マトリックスメタロプロテイナーゼ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心筋梗塞", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model"}]}, "item_type_id": "3", "owner": "3", "path": ["644"], "permalink_uri": "http://hdl.handle.net/10129/1797", "pubdate": 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Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model
http://hdl.handle.net/10129/1797
http://hdl.handle.net/10129/17970d8e1f17-8af4-41a0-bde7-f4775e673519
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_60_1-4_45.pdf (415.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-08 | |||||
タイトル | ||||||
タイトル | Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | structural remodeling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amiodarone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | matrix metalloproteinases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 構造的モデリング | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アミオダロン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マトリックスメタロプロテイナーゼ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋梗塞 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Horiuchi, Daisuke
× Horiuchi, Daisuke× Osanai, Tomohiro× Echizen, Takashi× Ashitate, Toshihiro× Kato, Chisato× Yokoyama, Hiroaki× Hanada, Kenji× Shibutani, Shuji× Itoh, Taihei× Okumura, Ken |
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著者(ヨミ) | ||||||
姓名 | ホリウチ, ダイスケ | |||||
著者(ヨミ) | ||||||
姓名 | オサナイ, トモヒロ | |||||
著者(ヨミ) | ||||||
姓名 | エチゼン, タカシ | |||||
著者(ヨミ) | ||||||
姓名 | アシタテ, トシヒロ | |||||
著者(ヨミ) | ||||||
姓名 | カトウ, チサト | |||||
著者(ヨミ) | ||||||
姓名 | ヨコヤマ, ヒロアキ | |||||
著者(ヨミ) | ||||||
姓名 | ハナダ, ケンジ | |||||
著者(ヨミ) | ||||||
姓名 | シブタニ, シュウジ | |||||
著者(ヨミ) | ||||||
姓名 | イトウ, タイヘイ | |||||
著者(ヨミ) | ||||||
姓名 | オクムラ, ケン | |||||
著者別名 | ||||||
姓名 | 堀内, 大輔 | |||||
著者別名 | ||||||
姓名 | 長内, 智宏 | |||||
著者別名 | ||||||
姓名 | 越前, 崇 | |||||
著者別名 | ||||||
姓名 | 芦立, 俊宗 | |||||
著者別名 | ||||||
姓名 | 加藤, 千里 | |||||
著者別名 | ||||||
姓名 | 横山, 公章 | |||||
著者別名 | ||||||
姓名 | 花田, 賢二 | |||||
著者別名 | ||||||
姓名 | 渋谷, 修司 | |||||
著者別名 | ||||||
姓名 | 伊藤, 太平 | |||||
著者別名 | ||||||
姓名 | 奥村, 謙 | |||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科循環呼吸腎臓内科学 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Structural remodeling occurs in diverse heart diseases and affects their clinical courses. We reported that amiodarone suppresses both electrical and structural remodeling in a canine persistent atrial fi brillation model. As a mechanism for amiodarone’s effect on structural remodeling, we suggested its inhibitory effect on matrix metalloproteinase( MMP) activity. To elucidate it, we investigated the eff ect of amiodarone on MMP activity in a rat myocardial infarction model created by left coronary artery( LCA) ligation. Adult Sprague-Dawley rats were divided into sham-operated (Sham), sham-operated with amiodarone (Sham+AMD), LCA-ligated without amiodarone (MI) and LCA-ligated with amiodarone rats (MI+AMD). Amiodarone (20 mg/kg/day) was administered for 2 weeks before and for 4 weeks after operation. The hearts were excised at 4 weeks after operation. MMP-2 activity was measured by gelatin zymography. At 4 weeks after surgery, left ventricular fractional shortening was decreased in MI but not in MI+AMD rats. There was no diff erence in the infarct size between MI and MI+AMD rats (P=NS). As compared with Sham, MMP-2 activity was increased in MI (P<0.01), but not in MI+AMD (P=NS versus Sham; P<0.05 versus MI). MMP-2 activity was not increased in Sham+AMD( P=NS). Thus, amiodarone exerts an inhibitory eff ect on MMP activity. This may be related to the improvement left ventricular function in MI rats. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 60(1/2/3/4), 2009, p.45-53 | |||||
書誌情報 |
弘前医学 巻 60, 号 1/2/3/4, p. 45-53, 発行日 2009-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 493.23 | |||||
その他のタイトル | ||||||
その他のタイトル | アミオダロンのマトリックスメタロプロテイナーゼ-2 活性に対する作用 :ラット心筋梗塞モデルでの検討 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | アミオダロン ノ マトリックス メタロプロテイナーゼ -2 カッセイ ニ タイスル サヨウ : ラット シンキン コウソク モデル デノ ケントウ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |