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<Symposium V>Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation
http://hdl.handle.net/10129/3681
http://hdl.handle.net/10129/3681dfbc1142-a438-4072-92ab-fc0a03bc75b0
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61_S147.pdf (146.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-18 | |||||
タイトル | ||||||
タイトル | <Symposium V>Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Edaravone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nrf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carnosic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NGF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reperfusion | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshida, Hidemi
× Yoshida, Hidemi× Mimura, Junsei× Imaizumi, Tadaatsu× Matsumiya, Tomoh× Ishikawa, Akira× Metoki, Norifumi× Tanji, Kunikazu× Ota, Ken× Kosaka, Kunio× Itoh, Ken× Satoh, Kei |
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著者(ヨミ) | ||||||
姓名 | ヨシダ, ヒデミ | |||||
著者(ヨミ) | ||||||
姓名 | ミムラ, ジュンセイ | |||||
著者(ヨミ) | ||||||
姓名 | イマイズミ, タダアツ | |||||
著者(ヨミ) | ||||||
姓名 | マツミヤ, トモオ | |||||
著者(ヨミ) | ||||||
姓名 | イシカワ, アキラ | |||||
著者(ヨミ) | ||||||
姓名 | メトキ, ノリフミ | |||||
著者(ヨミ) | ||||||
姓名 | タンジ, クニカズ | |||||
著者(ヨミ) | ||||||
姓名 | オオタ, ケン | |||||
著者(ヨミ) | ||||||
姓名 | イトウ, ケン | |||||
著者(ヨミ) | ||||||
姓名 | サトウ, ケイ | |||||
著者別名 | ||||||
姓名 | 吉田, 秀見 | |||||
著者別名 | ||||||
姓名 | 今泉, 忠淳 | |||||
著者別名 | ||||||
姓名 | 石川, 玲 | |||||
著者別名 | ||||||
姓名 | 丹治, 邦和 | |||||
著者別名 | ||||||
姓名 | 伊東, 健 | |||||
著者別名 | ||||||
姓名 | 佐藤, 敬 | |||||
著者所属 | ||||||
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Stress Response Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Disability and Health, Hirosaki University Graduate School of Health Sciences | ||||||
著者所属 | ||||||
Department of Internal Medicine, Hirosaki Stroke Center | ||||||
著者所属 | ||||||
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Research and Development Center, Nagase & Co. Ltd. | ||||||
著者所属 | ||||||
Department of Stress Response Science, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Optimization of neuronal function and survival is an important goal in the treatment of cerebrovascular diseases in order to avoid or improve devastating long-term sequelae. Nerve growth factor (NGF) is essential for neuronal growth and survival in the central nervous system (CNS). Vascular endothelial growth factor (VEGF) is a potent mitogen specifi c for endothelial cells and a stimulator of neovascularization. VEGF also enhances vascular permeability, which may promote the development of brain edema during cerebral ischemia. These molecules aff ect the outcome of ischemia/reperfusion injury in the CNS. Edaravone, a brain-penetrant, free radical scavenger, is known to ameliorate postischemic neuronal dysfunction. Transcription factor Nrf2( nuclear factor-erythroid 2-related factor 2), a master regulator of antioxidant responses, plays an important role in the coordinated expressions of stress-inducible genes. Astrocytes express various genes involved in the regulation of neuronal functions, and the regulation of astrocyte gene expressions may be a potential therapeutic target in brain injury. This review aims to appraise the eff ects of radical scavenger edaravone and a natural Nrf2-inducer as neuroprotective agents in human astrocytes, particularly under an experimental model for hypoxia/reoxygenation. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(Suppl.), 2010, p.S147-S156 | |||||
書誌情報 |
弘前医学 巻 61, 号 Supplement, p. S147-S156, 発行日 2010-07-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |