Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
Department of Anesthesiology, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki University Graduate School of Medicine
Department of Dermatology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
Department of Pharmacy, Hirosaki University, Graduate School of Medicine
Department of Dermatology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki UniversityGraduate School of Medicine
抄録
We analyzed the effects of halothane as an inhalational anesthetic agent on electrocardiogram （ECG）
parameters in C57/BL6 mice. Following induction of anesthesia using 2% halothane, the ECGs showed a regular
pattern and the heart rate （HR） was within an acceptable range （~500 bpm）. The HR decreased with increasing
halothane concentration in a concentration-dependent fashion.
The frequency domain analysis showed that the high-frequency （HF） component decreased and the lowfrequency
（LF） component increased in a concentration-dependent fashion. Therefore, the LF/HF ratio increased
with increasing halothane concentration, suggesting effects on the autonomic nervous system.
We analyzed the pharmacological response to sympathetic blockade with propranolol, a typical adrenergic
β-blocker, under halothane anesthesia. Propranolol administration resulted in a decreased HR; interestingly,
intraperitoneal injection of propranolol （120 μg/kg body weight） resulted in arrhythmia （sick sinus syndrome）
during anesthesia with 3% halothane.
Our results indicate the importance of selecting a suitable anesthetic agent for C57/BL6 mice in pharmacological studies
運用指針・許諾書
Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice
HirosakiMedJ_67(2-4)_129.pdf
(240.19KB)
