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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 67巻2-4号

Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice

http://hdl.handle.net/10129/6012
http://hdl.handle.net/10129/6012
4b060dd3-0848-4c56-8393-76a9bdefb2d4
名前 / ファイル ライセンス アクション
HirosakiMedJ_67(2-4)_129.pdf HirosakiMedJ_67(2-4)_129.pdf (240.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-03-09
タイトル
タイトル Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice
言語
言語 eng
キーワード
主題Scheme Other
主題 Inhalation halothane anesthesia
キーワード
主題Scheme Other
主題 barbiturate; mouse
キーワード
主題Scheme Other
主題 mouse
キーワード
主題Scheme Other
主題 ECG
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Nozaki, Shuhei

× Nozaki, Shuhei

Nozaki, Shuhei

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Ogata, Yoshiki

× Ogata, Yoshiki

Ogata, Yoshiki

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Yonekura, Manabu

× Yonekura, Manabu

Yonekura, Manabu

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Han, Chong

× Han, Chong

Han, Chong

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Niwa, Hidetoshi

× Niwa, Hidetoshi

Niwa, Hidetoshi

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Kushikata, Tetsuya

× Kushikata, Tetsuya

Kushikata, Tetsuya

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Hirota, Kazuyoshi

× Hirota, Kazuyoshi

Hirota, Kazuyoshi

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Matsuzaki, Yasushi

× Matsuzaki, Yasushi

Matsuzaki, Yasushi

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Tomita, Hirofumi

× Tomita, Hirofumi

Tomita, Hirofumi

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Imaizumi, Tadaatsu

× Imaizumi, Tadaatsu

Imaizumi, Tadaatsu

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Itagaki, Shirou

× Itagaki, Shirou

Itagaki, Shirou

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Sawamura, Daisuke

× Sawamura, Daisuke

Sawamura, Daisuke

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Murakami, Manabu

× Murakami, Manabu

Murakami, Manabu

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著者所属
値 Department of Pharmacology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Pharmacology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Pharmacology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
著者所属
値 Department of Anesthesiology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Anesthesiology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Dermatology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Pharmacy, Hirosaki University, Graduate School of Medicine
著者所属
値 Department of Dermatology, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Pharmacology, Hirosaki UniversityGraduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 We analyzed the effects of halothane as an inhalational anesthetic agent on electrocardiogram (ECG)
parameters in C57/BL6 mice. Following induction of anesthesia using 2% halothane, the ECGs showed a regular
pattern and the heart rate (HR) was within an acceptable range (~500 bpm). The HR decreased with increasing
halothane concentration in a concentration-dependent fashion.
  The frequency domain analysis showed that the high-frequency (HF) component decreased and the lowfrequency
(LF) component increased in a concentration-dependent fashion. Therefore, the LF/HF ratio increased
with increasing halothane concentration, suggesting effects on the autonomic nervous system.
  We analyzed the pharmacological response to sympathetic blockade with propranolol, a typical adrenergic
β-blocker, under halothane anesthesia. Propranolol administration resulted in a decreased HR; interestingly,
intraperitoneal injection of propranolol (120 μg/kg body weight) resulted in arrhythmia (sick sinus syndrome)
during anesthesia with 3% halothane.
 Our results indicate the importance of selecting a suitable anesthetic agent for C57/BL6 mice in pharmacological studies
引用
内容記述タイプ Other
内容記述 弘前医学. 67, 2017, p.129-135
書誌情報 弘前医学

巻 67, 号 2-4, p. 129-135, 発行日 2017-02-27
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
日本十進分類法
主題Scheme NDC
主題 490
NIIサブジェクト
主題Scheme Other
主題 医学
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
資源タイプ
値 Article
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