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Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats
http://hdl.handle.net/10129/6146
http://hdl.handle.net/10129/6146b4c11721-deca-4867-a632-2caaac8c234d
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_68(1)_33.pdf (397.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-23 | |||||
タイトル | ||||||
タイトル | Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ECG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | parasympathetic nerve | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes mellitus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Han, Chong
× Han, Chong× Inaba, Wataru× Yonekura, Manabu× Ogata, Yoshiki× Ohba, Takayoshi× Kushikata, Tetsuya× Niwa, Hidetoshi× Yanagisawa, Teruyuki× Tomita, Hirofumi× Itagaki, Shirou× Hirota, Kazuyoshi× Akai, Hiroaki× Mizukami, Hiroki× Murakami, Manabu |
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著者所属 | ||||||
Department of Pharmacology | ||||||
著者所属 | ||||||
Department of Pathology and Molecular Medicine | ||||||
著者所属 | ||||||
Department of Cardiology | ||||||
著者所属 | ||||||
Department of Pharmacology | ||||||
著者所属 | ||||||
Department of Cellphysiology, Akita University School of Medicine, Akita | ||||||
著者所属 | ||||||
Department of Anesthesiology | ||||||
著者所属 | ||||||
Department of Anesthesiology | ||||||
著者所属 | ||||||
Department of MolecularPharmacology, Tohoku University School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology | ||||||
著者所属 | ||||||
Department of Pharmacy, Hirosaki University, Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Anesthesiology | ||||||
著者所属 | ||||||
Department of Metabolism and Diabetes, Tohoku Medical Pharmaceutical University | ||||||
著者所属 | ||||||
Department of Pathology and Molecular Medicine | ||||||
著者所属 | ||||||
Department of Pharmacology | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Persistent hyperglycemia is implicated in the pathogenesis of chronic diabetic complications, such as neuropathy. Therefore, we investigated Electrocardiogram( ECG)-related changes, including various ECG parameters and heart rate variability, and neuropathic changes in diabetic Goto-Kakizaki (GK) rats, a spontaneous model for type 2 diabetes. GK rats (50 weeks old) showed increased plasma glucose and decreased R-R interval variability, which was likely due to diabetic polyneuropathy in the autonomic nervous system. Interestingly, GK rats showed a decreased baroreflex compared with control Wistar rats. Furthermore, GK rats showed limited fluctuation changes in beat-to-beat dynamics. In the frequency domain analysis, the low-frequency component was similar but the highfrequency component was significantly decreased in GK rats, suggesting decreased parasympathetic nerve regulation and conserved sympathetic nerve regulation. In addition, GK rats showed a limited response to high-dose atropine, a muscarinic receptor antagonist, indicating modified parasympathetic nerve regulation in GK rats. Our data strongly suggests that GK rat could be a nice animal model for chronic cardiovascular disease related to diabetic neuropathy. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 68, p.33-43. 2017 | |||||
書誌情報 |
弘前医学 巻 68, 号 1, p. 33-43, 発行日 2017-10-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |