| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-23 |
| タイトル |
|
|
タイトル |
Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
rats |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ECG |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
parasympathetic nerve |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
diabetes mellitus |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Han, Chong
Inaba, Wataru
Yonekura, Manabu
Ogata, Yoshiki
Ohba, Takayoshi
Kushikata, Tetsuya
Niwa, Hidetoshi
Yanagisawa, Teruyuki
Tomita, Hirofumi
Itagaki, Shirou
Hirota, Kazuyoshi
Akai, Hiroaki
Mizukami, Hiroki
Murakami, Manabu
|
| 著者所属 |
|
|
|
Department of Pharmacology |
| 著者所属 |
|
|
|
Department of Pathology and Molecular Medicine |
| 著者所属 |
|
|
|
Department of Cardiology |
| 著者所属 |
|
|
|
Department of Pharmacology |
| 著者所属 |
|
|
|
Department of Cellphysiology, Akita University School of Medicine, Akita |
| 著者所属 |
|
|
|
Department of Anesthesiology |
| 著者所属 |
|
|
|
Department of Anesthesiology |
| 著者所属 |
|
|
|
Department of MolecularPharmacology, Tohoku University School of Medicine |
| 著者所属 |
|
|
|
Department of Cardiology |
| 著者所属 |
|
|
|
Department of Pharmacy, Hirosaki University, Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Anesthesiology |
| 著者所属 |
|
|
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Department of Metabolism and Diabetes, Tohoku Medical Pharmaceutical University |
| 著者所属 |
|
|
|
Department of Pathology and Molecular Medicine |
| 著者所属 |
|
|
|
Department of Pharmacology |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Persistent hyperglycemia is implicated in the pathogenesis of chronic diabetic complications, such as
neuropathy. Therefore, we investigated Electrocardiogram（ ECG）-related changes, including various ECG parameters
and heart rate variability, and neuropathic changes in diabetic Goto-Kakizaki （GK） rats, a spontaneous model for
type 2 diabetes. GK rats （50 weeks old） showed increased plasma glucose and decreased R-R interval variability,
which was likely due to diabetic polyneuropathy in the autonomic nervous system. Interestingly, GK rats showed a
decreased baroreflex compared with control Wistar rats. Furthermore, GK rats showed limited fluctuation changes
in beat-to-beat dynamics. In the frequency domain analysis, the low-frequency component was similar but the highfrequency
component was significantly decreased in GK rats, suggesting decreased parasympathetic nerve regulation
and conserved sympathetic nerve regulation. In addition, GK rats showed a limited response to high-dose atropine, a
muscarinic receptor antagonist, indicating modified parasympathetic nerve regulation in GK rats. Our data strongly
suggests that GK rat could be a nice animal model for chronic cardiovascular disease related to diabetic neuropathy. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 68, p.33-43. 2017 |
| 書誌情報 |
弘前医学
巻 68,
号 1,
p. 33-43,
発行日 2017-10-05
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_68(1)_33.pdf (397.1 kB)
