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Clinical implications of serum N-glycan profiling as a diagnostic and prognostic biomarker in germ-cell tumors
http://hdl.handle.net/10129/00006545
http://hdl.handle.net/10129/00006545397c4191-11e4-48c1-9e64-d1a46998ca03
名前 / ファイル | ライセンス | アクション |
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cam4.1035 (425.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-03-08 | |||||
タイトル | ||||||
タイトル | Clinical implications of serum N-glycan profiling as a diagnostic and prognostic biomarker in germ-cell tumors | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Narita, Takuma
× Narita, Takuma× Hatakeyama, Shingo× Yoneyama, Tohru× Narita, Shintaro× Yamashita, Shinichi× Mitsuzuka, Koji× Sakurai, Toshihiko× Kawamura, Sadafumi× Tochigi, Tatsuo× Takahashi, Ippei× Nakaji, Shigeyuki× Tobisawa, Yuki× Yamamoto, Hayato× Koie, Yoichi× Tsuchiya, Norihiko× Habuchi, Tomonori× Arai, Yoichi× Ohyama, Chikara |
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著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Adv Transplant & Regenerat Med | ||||||
著者所属 | ||||||
Akita Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Tohoku Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Tohoku Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Yamagata Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Miyagi Canc Ctr, Dept Urol | ||||||
著者所属 | ||||||
Miyagi Canc Ctr, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Sch Med, Dept Social Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Sch Med, Dept Social Med | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Yamagata Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Akita Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Tohoku Univ, Grad Sch Med, Dept Urol | ||||||
著者所属 | ||||||
Hirosaki Univ, Grad Sch Med, Dept Urol | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Serum biomarker monitoring is essential for management of germ-cell tumors (GCT). However, not all GCT are positive for conventional tumor markers. We examined whether serum N-glycan-based biomarkers can be applied for detection and prognosis in patients with GCT. We performed a comprehensive N-glycan structural analysis of sera from 54 untreated GCT patients and 103 age-adjusted healthy volunteers using glycoblotting methods and mass spectrometry. Candidate N-glycans were selected from those with the highest association; cutoff concentration values were established, and an N-glycan score was created based on the number of positive N-glycans present. The validity of this score for diagnosis and prognosis was analyzed using a receiver operating characteristic (ROC) curve. We identified five candidate N-glycans significantly associated with GCT patients. The accuracy of the N-glycan score for GCT was significant with an area-under-the-curve (AUC) value of 0.87. Diagnostically, the N-glycan score detected 10 of 12 (83%) patients with negative conventional tumor markers. Prognostically, the N-glycan score comprised four candidate N-glycans. The predictive value of the prognostic N-glycan score was significant, with an AUC value of 0.89. A high value prognostic N-glycan score was significantly associated with poor prognosis. Finally, to identify a potential carrier protein, immunoglobulin (Ig) fractions of sera were subjected to N-glycan analysis and compared to whole sera. Candidate N-glycans in Ig-fractions were significantly decreased; therefore, the carrier protein for candidate N-glycans is likely not an immunoglobulin. In summary, our newly developed N-glycan score seems to be a practical diagnostic and prognostic method for GCT. | |||||
書誌情報 |
CANCER MEDICINE 巻 6, 号 4, p. 739-748, 発行日 2017-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-7634 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/cam4.1035 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
値 | Article |