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Rejuvenation of T cell memory
http://hdl.handle.net/10129/2213
http://hdl.handle.net/10129/2213da48e2d8-1c0d-42e1-be4e-635b4d2dd183
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_59_S26.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-09-18 | |||||
タイトル | ||||||
タイトル | Rejuvenation of T cell memory | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | memory CD8+ T cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | primary response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | maintenance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kurachi, Makoto
× Kurachi, Makoto× Kakimi, Kazuhiro× Ueha, Satoshi× Matsushima, Kouji |
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著者所属 | ||||||
Department of Immunotherapeutics(Medinet), Graduate School of Medicine, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Immunotherapeutics(Medinet), Graduate School of Medicine, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Molecular Preventive Medicine & SORST, Graduate School of Medicine, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Molecular Preventive Medicine & SORST, Graduate School of Medicine, The University of Tokyo | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Memory CD8+ T cells generated during an immune response are long-lived and self-renewing, off ering enhanced host protection against re-infection. However, how an antigen-specific population of memory T cells is maintained throughout repetitive infections over potentially a lifetime is not known. Here we review the generation and maintenance of antigen-specifi c CD8+ T cells and introduce our recent data showing dynamic turnover of an antigen-specific memory T cell population during repeated antigen challenge in vivo. We demonstrated that a primary response potentially occurs upon every recall response and fi nd that the skewed T-cell receptor (TCR) repertoire of pre-existing memory T cells is partly corrected by diversity in a newly formed (primary) population. Importantly, memory T cells generated in a more recent antigen encounter expand more vigorously in a subsequent recall response. A primary response during re-challenge therefore restores both the TCR diversity and proliferative potential of the memory T cell population. These findings indicate that memory T cell populations evolve over multiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primary populations have essential roles in the perpetuation of antigen-specifi c T cell populations. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 59(Suppl.), 2007, p.S26-S34 | |||||
書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S26-S34, 発行日 2007-11-29 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491.8 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 基礎医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |