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Rejuvenation of T cell memory
http://hdl.handle.net/10129/2213
http://hdl.handle.net/10129/2213da48e2d8-1c0d-42e1-be4e-635b4d2dd183
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S26.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2009-09-18 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Rejuvenation of T cell memory | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | memory CD8+ T cell | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | primary response | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | maintenance | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Kurachi, Makoto
× Kurachi, Makoto
× Kakimi, Kazuhiro
× Ueha, Satoshi
× Matsushima, Kouji
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| 著者所属 | ||||||||||||||
| Department of Immunotherapeutics(Medinet), Graduate School of Medicine, The University of Tokyo | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Immunotherapeutics(Medinet), Graduate School of Medicine, The University of Tokyo | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Molecular Preventive Medicine & SORST, Graduate School of Medicine, The University of Tokyo | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Molecular Preventive Medicine & SORST, Graduate School of Medicine, The University of Tokyo | ||||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Memory CD8+ T cells generated during an immune response are long-lived and self-renewing, off ering enhanced host protection against re-infection. However, how an antigen-specific population of memory T cells is maintained throughout repetitive infections over potentially a lifetime is not known. Here we review the generation and maintenance of antigen-specifi c CD8+ T cells and introduce our recent data showing dynamic turnover of an antigen-specific memory T cell population during repeated antigen challenge in vivo. We demonstrated that a primary response potentially occurs upon every recall response and fi nd that the skewed T-cell receptor （TCR） repertoire of pre-existing memory T cells is partly corrected by diversity in a newly formed （primary） population. Importantly, memory T cells generated in a more recent antigen encounter expand more vigorously in a subsequent recall response. A primary response during re-challenge therefore restores both the TCR diversity and proliferative potential of the memory T cell population. These findings indicate that memory T cell populations evolve over multiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primary populations have essential roles in the perpetuation of antigen-specifi c T cell populations. |
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| 引用 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S26-S34 | |||||||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S26-S34, 発行日 2007-11-29 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00211444 | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 日本十進分類法 | ||||||||||||||
| 主題Scheme | NDC | |||||||||||||
| 主題 | 491.8 | |||||||||||||
| NIIサブジェクト | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | 基礎医学 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 値 | Article | |||||||||||||
