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"subitem_subject_scheme": "Other"}, {"subitem_subject": "TLR4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNF-α", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IFN-β", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "<Poster>Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "<Poster>Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews"}]}, "item_type_id": "3", "owner": "3", "path": ["647"], "permalink_uri": "http://hdl.handle.net/10129/3692", "pubdate": 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<Poster>Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews
http://hdl.handle.net/10129/3692
http://hdl.handle.net/10129/3692453cc64d-b4b9-4edb-a916-192ce6632965
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61_S224.pdf (200.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-19 | |||||
タイトル | ||||||
タイトル | <Poster>Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Listeria monocytogenes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p60 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TLR4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-β | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sashinami, Hiroshi
× Sashinami, Hiroshi× Hu, Dong-Liang× Li, Sheng-Jun× Mitsui, Toshihito× Hakamada, Kenichi× Ishiguro, Yoh× Fukuda, Shinsaku× Nakane, Akio |
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著者(ヨミ) | ||||||
姓名 | サシナミ, ヒロシ | |||||
著者(ヨミ) | ||||||
姓名 | フウ, ドンリャン | |||||
著者(ヨミ) | ||||||
姓名 | ミツイ, トシヒト | |||||
著者(ヨミ) | ||||||
姓名 | ハカマダ, ケンイチ | |||||
著者(ヨミ) | ||||||
姓名 | イシグロ, ヨウ | |||||
著者(ヨミ) | ||||||
姓名 | フクダ, シンサク | |||||
著者(ヨミ) | ||||||
姓名 | ナカネ, アキオ | |||||
著者別名 | ||||||
姓名 | 差波, 拓志 | |||||
著者別名 | ||||||
姓名 | 胡, 東良 | |||||
著者別名 | ||||||
姓名 | 李, 勝軍 | |||||
著者別名 | ||||||
姓名 | 三ツ井, 敏仁 | |||||
著者別名 | ||||||
姓名 | 袴田, 健一 | |||||
著者別名 | ||||||
姓名 | 石黒, 陽 | |||||
著者別名 | ||||||
姓名 | 福田, 眞作 | |||||
著者別名 | ||||||
姓名 | 中根, 明夫 | |||||
著者所属 | ||||||
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Digestive Surgery, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the eff ect of p60 that is one of virulence factors of Listeria monocytogenes on host immune response in vitro and in vivo. C57BL/6 mice immunized with p60 showed antigen-specifi c T-helper I type immune response. Mouse macrophage RAW264.7 cells produced tumor necrosis factor alpha (TNF-α), interleukin-12 and interferon beta (IFN-β) in response to stimulation with recombinant p60. Administration of p60 prior to a sublethal infection with L. monocytogenes enhanced innate host resistance in naïve mice. TNF-α and IFN-β production from RAW264.7 cells and bone marrow-derived macrophages were Toll-like receptor 4 (TLR4)-dependent. The enhanced clearance of L. monocytogenes by p60 administration was not shown in C3H/HeJ mice. Our fi ndings demonstrated that p60 enhances host resistance against L. monocytngenes infection through both activation and attenuation of host innate immune response in the TLR4-dependent manner. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(Suppl.), 2010, p.S224-S231 | |||||
書誌情報 |
弘前医学 巻 61, 号 Supplement, p. S224-S231, 発行日 2010-07-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |