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"subitem_subject_scheme": "Other"}, {"subitem_subject": "プロテイン・アレイ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "サルコイドーシス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "呼気凝縮液", "subitem_subject_scheme": "Other"}, {"subitem_subject": "気管支肺胞洗浄", "subitem_subject_scheme": "Other"}, {"subitem_subject": "炎症性サイトカイン", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?"}]}, "item_type_id": "3", 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Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?
http://hdl.handle.net/10129/4618
http://hdl.handle.net/10129/4618be3150ab-b0c1-4b0f-a163-1ee42742de0b
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_63(1)_12.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-06-07 | |||||
タイトル | ||||||
タイトル | Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients? | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inflammatory molecules | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein array analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sarcoidosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | exhaled breath condensate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bronchoalveolar lavage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | プロテイン・アレイ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | サルコイドーシス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 呼気凝縮液 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 気管支肺胞洗浄 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 炎症性サイトカイン | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakamura, Kunihiko
× Nakamura, Kunihiko× Mikuniya, Megumi× Takanashi, Shingo× Hayashi, Akihito× Morimoto, Takeshi× Taima, Kageaki× Dempoya, Junichi× Okumura, Ken |
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著者(ヨミ) | ||||||
姓名 | ナカムラ, クニヒコ | |||||
著者(ヨミ) | ||||||
姓名 | ミクニヤ, メグミ | |||||
著者(ヨミ) | ||||||
姓名 | タカナシ, シンゴ | |||||
著者(ヨミ) | ||||||
姓名 | ハヤシ, アキヒト | |||||
著者(ヨミ) | ||||||
姓名 | モリモト, タケシ | |||||
著者(ヨミ) | ||||||
姓名 | タイマ, カゲアキ | |||||
著者(ヨミ) | ||||||
姓名 | デンポウヤ, ジュンイチ | |||||
著者(ヨミ) | ||||||
姓名 | オクムラ, ケン | |||||
著者別名 | ||||||
姓名 | 中村, 邦彦 | |||||
著者別名 | ||||||
姓名 | 三國谷, 恵 | |||||
著者別名 | ||||||
姓名 | 高梨, 信吾 | |||||
著者別名 | ||||||
姓名 | 林, 彰仁 | |||||
著者別名 | ||||||
姓名 | 森本, 武史 | |||||
著者別名 | ||||||
姓名 | 當麻, 景章 | |||||
著者別名 | ||||||
姓名 | 傳法谷, 純一 | |||||
著者別名 | ||||||
姓名 | 奥村, 謙 | |||||
著者所属 | ||||||
弘前大学循環呼吸腎臓内科学講座 | ||||||
著者所属 | ||||||
弘前大学保健管理センター | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Although analysis of bronchoalveolar lavage fluid (BALF) is a useful examination to assess airway inflammation, it is an invasive technique with limitation and risk of complications. Objectives: The aim of this study was to examine molecules in exhaled breath condensate( EBC) in comparison with BALF, and to clarify the clinical usability of EBC. Methods: EBC was collected from sixteen subjects suspected to have sarcoidosis just before BAL. The 40 different inflammatory molecules in EBC and BALF were analyzed by protein array. Results: BALF levels of 6 molecules including soluble tumor necrosis factor receptor type II (sTNF-RII) and regulated upon activation, normal T cell expressed and secreted (RANTES), and EBC levels of 13 molecules including sTNF-RII and RANTES were significantly correlated with percentage of lymphocyte in BALF (%Lym). We found significant correlations between levels of EBC and BALF in 16 out of 40 molecules. Levels of macrophage colony-stimulating factor( M-CSF), RANTES, TNF-α and sTNF-RII in EBC were significantly correlated with BALF. Their levels in EBC and BALF also were correlated with %Lym. Conclusion: Protein array, a highly sensitive approach allowed us to detect inflammatory molecules in EBC. Comprehensive analysis of EBC might be an equivalent to that of BALF. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 63, 2012, p.12-20 | |||||
書誌情報 |
弘前医学 巻 63, 号 1, p. 12-20, 発行日 2012-05-18 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 493.38 | |||||
その他のタイトル | ||||||
その他のタイトル | 呼気凝縮液の有用性に関する研究 : 気管支肺胞洗浄液との比較検討 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | コキ ギョウシュク エキ ノ ユウヨウセイ ニ カンスル ケンキュウ キカンシ ハイホウ センジョウ エキ トノ ヒカク ケントウ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |