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Reduced IL-1β Production in Diet-Induced Obese Mice Impairs Host Defense against Skin Staphylococcus Aureus Infection
http://hdl.handle.net/10129/4900
http://hdl.handle.net/10129/4900029d72e3-7fb3-471c-8380-00069212e644
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_64(1)_29.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-08-02 | |||||
タイトル | ||||||
タイトル | Reduced IL-1β Production in Diet-Induced Obese Mice Impairs Host Defense against Skin Staphylococcus Aureus Infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Obesity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | skin Staphylococcus aureus infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interleukin-1β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammasome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 肥満 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 黄色ブドウ球菌皮膚感染 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インターロイキン‐1β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インフラマソーム | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sakamoto, Yuichi
× Sakamoto, Yuichi× Narita, Koji× Nakane, Akio |
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著者(ヨミ) | ||||||
姓名 | サカモト, ユウイチ | |||||
著者(ヨミ) | ||||||
姓名 | ナリタ, コウジ | |||||
著者(ヨミ) | ||||||
姓名 | ナカネ, アキオ | |||||
著者別名 | ||||||
姓名 | 坂本, 勇一 | |||||
著者別名 | ||||||
姓名 | 成田, 浩司 | |||||
著者別名 | ||||||
姓名 | 中根, 明夫 | |||||
著者所属 | ||||||
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
弘前大学大学院医学研究科感染生体防御学講座 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Obesity leads to a state of chronic inflammation associated with increased levels of proinflammatory cytokines including interleukin-1β (IL-1β) that plays a critical role in host defense against Staphylococcus aureus infection. In this study, we investigated host defense against skin S. aureus infection in high-fat diet (HFD)-induced non-diabetic obesity by focusing on IL-1β production from subcutaneous adipose tissue derived-macrophages (SATDMs). Bacterial numbers in skin lesions of HFD-fed mice were higher than those of normal-fat diet (ND)-fed control mice on day 3 after subcutaneous S. aureus infection. IL-1β production from SATDMs of HFD-fed mice was less than that of ND-fed mice after stimulation with formalin-killed S. aureus and ATP. In addition, NLRP3 mRNA expression and protein level of activated caspase-1 in SATDMs of HFD-fed mice were lower than those of NDfed mice after stimulation. Conversely, IL-1β production, NLRP3 mRNA expression and protein level of activated caspase-1 from visceral adipose tissue-derived macrophages of HFD-fed mice were higher than those of ND-fed mice. These results suggest that reduced IL-1β production in SATDMs of HFD-fed obese mice might be involved in impairment of host defense against skin S. aureus infection. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 64, 2013, p.29-40 | |||||
書誌情報 |
弘前医学 巻 64, 号 1, p. 29-40, 発行日 2013-05-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491.7 | |||||
その他のタイトル | ||||||
その他のタイトル | 食餌性肥満マウスにおけるIL-1β産生減少にともなう皮膚黄色ブドウ球菌感染防御機能の低下 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | ショクジセイ ヒマン マウス ニオケル IL-1β サンセイ ゲンショウ ニ トモナウ ヒフ オウショク ブドウ キュウキン カンセン ボウギョ キノウ ノ テイカ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |