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Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways
http://hdl.handle.net/10129/0002000354
http://hdl.handle.net/10129/00020003548534b5cd-32cf-4e27-954d-bec7109fb44d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hirosaki Med J 74-1-4_52.pdf (594 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2024-04-29 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Benzodiazepine-induced cell growth inhibition via GABAA receptor- and TSPO-independent pathways | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | GABAA receptor | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | TSPO | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | benzodiazepine | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cell cycle | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
Shuji, Shimoyama
× Shuji, Shimoyama
× Tomonori, Furukawa
× Shinya, Ueno
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| 著者所属 | ||||||||||||
| en | ||||||||||||
| Department of Neurophysiology, Hirosaki University Graduate School of Medicine | ||||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Our previous study showed that chronic administration of diazepam （DZP） induces changes in gene expression in the hippocampus, cortex, and amygdala. Pathway analysis indicated that cell cycle was altered by chronic DZP treatment. These results raise the concern that chronic DZP administration provokes alterations in cell proliferation. The aim of this study is to elucidate the mechanism by which benzodiazepines（ BZDs） regulate cell cycle. Cell growth curve analysis and MTT assays revealed that DZP treatment significantly reduced cell growth in the microglial cell line. Interestingly, cell growth was not affected by antagonizing the DZP target molecules, gammaaminobutyric acid （GABA） Type A receptor （GABAA-R）, and 18 kDa translocator protein （TSPO）. Similar to the results of DZP, other BZDs such as lorazepam （LZP） and midazolam （MDZ） showed a significant decrease in cell growth. In addition to the mouse microglial cell line results, mouse neuroblastoma cell line also showed an inhibition of cell growth. In contrast, only MDZ inhibited cell growth in human astrocytoma cell line, U373 cells. However, it is not clear whether these differences depend on species or cell types. Consequently, BZDs inhibit cell growth via GABAA-R- and TSPO-independent pathways. |
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| 言語 | en | |||||||||||
| 書誌情報 |
ja : 弘前医学 en : Hirosaki Medical Journal 巻 74, 号 1-4, p. 52-60, 発行日 2024-03-28 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2434-4656 | |||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00211444 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 弘前大学大学院医学研究科 | |||||||||||
| 言語 | ja | |||||||||||
| 資源タイプ | ||||||||||||
| 言語 | en | |||||||||||
| 値 | Article | |||||||||||
