Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2024-04-29 |
タイトル |
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タイトル |
Moderate transgenic expression of CBR1 is not sufficient to prolong life expectancy in an SV40 T-antigen-induced gynecological carcinogenesis mouse model |
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言語 |
en |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
carbonyl reductase 1 |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
reproductive organs |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
crossbreeding experiment |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
transgenic mice |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
著者 |
Yuka, Kadonosawa
Minako, Yokoyama
Yota, Tatara
Ichiro, Miyoshi
Yoshihiko, Araki
Yoshihito, Yokoyama
Hodaka, Fujii
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著者所属 |
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言語 |
en |
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値 |
Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine |
著者所属 |
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言語 |
en |
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値 |
Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine |
著者所属 |
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言語 |
en |
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値 |
Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine |
著者所属 |
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言語 |
en |
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値 |
Institute for Animal Experimentation, Tohoku University Graduate School of Medicine |
著者所属 |
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言語 |
en |
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値 |
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine |
著者所属 |
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言語 |
en |
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値 |
Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine |
著者所属 |
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言語 |
en |
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値 |
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: High expression of carbonyl reductase 1 (CBR1) in ovarian cancer inhibits tumor growth and metastasis, although its long-term antitumor effects have not been investigated in detail. Methods: Transgenic mice (Tg-mice) overexpressing the mouse Cbr1 (CAG-mCbr1) transgene (Tg) (CAG-mCbr1 Tg-mice) were crossed with carcinogenesis model mice (mouse oviduct-specific glycoprotein (mOvgp1)-T-antigen (TAg) Tg-mice), which overexpress simian virus 40 (SV40) TAg in reproductive organs, and the resulting individuals were evaluated. Survival was evaluated with a cutoff of 24 weeks. Indicators of tumor size (testicular diameter in males, abdominal circumference in females) and body weights were evaluated at 12–13 weeks. Results: There were no significant differences in survival between CAG-mCbr1/mOvgp1-TAg double Tg (dTg)-mice and mOvgp1-TAg Tg-mice (P = 0.992). Male CAG-mCbr1/mOvgp1-TAg dTg-mice tended to have higher survival rates than in mOvgp1-TAg Tg-mice. Although, female mOvgp1-TAg Tg-mice tended to have higher survival rates than for CAG-mCbr1/mOvgp1-TAg dTg-mice, female body weights and male testicular diameter tended to be larger in mOvgp1-TAg Tg-mice than in WT mice. Conclusions: The lack of significant differences may be attributed to the strong carcinogenic effect of SV40 T-antigen. Although whether CBR1 has antitumor effects was not established, it may be involved in tumor growth rather than in metastasis. |
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言語 |
en |
書誌情報 |
ja : 弘前医学
en : Hirosaki Medical Journal
巻 74,
号 1-4,
p. 99-107,
発行日 2024-03-28
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ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-4656 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00211444 |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
出版者 |
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出版者 |
弘前大学大学院医学研究科 |
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言語 |
ja |
資源タイプ |
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言語 |
en |
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値 |
Article |