| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-04-29 |
| タイトル |
|
|
タイトル |
Moderate transgenic expression of CBR1 is not sufficient to prolong life expectancy in an SV40 T-antigen-induced gynecological carcinogenesis mouse model |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
carbonyl reductase 1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
reproductive organs |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
crossbreeding experiment |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
transgenic mice |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kadonosawa, Yuka
Yokoyama, Minako
Tatara, Yota
Miyoshi, Ichiro
Araki, Yoshihiko
Yokoyama, Yoshihito
Fujii, Hodaka
|
| 著者所属 |
|
|
言語 |
en |
|
値 |
Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine |
| 著者所属 |
|
|
言語 |
en |
|
値 |
Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine |
| 著者所属 |
|
|
言語 |
en |
|
値 |
Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
言語 |
en |
|
値 |
Institute for Animal Experimentation, Tohoku University Graduate School of Medicine |
| 著者所属 |
|
|
言語 |
en |
|
値 |
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine |
| 著者所属 |
|
|
言語 |
en |
|
値 |
Department of Obstetrics and Gynecology, Hirosaki University, Graduate School of Medicine |
| 著者所属 |
|
|
言語 |
en |
|
値 |
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: High expression of carbonyl reductase 1 （CBR1） in ovarian cancer inhibits tumor growth and metastasis, although its long-term antitumor effects have not been investigated in detail.
Methods: Transgenic mice （Tg-mice） overexpressing the mouse Cbr1 （CAG-mCbr1） transgene （Tg） （CAG-mCbr1 Tg-mice） were crossed with carcinogenesis model mice （mouse oviduct-specific glycoprotein （mOvgp1）-T-antigen （TAg） Tg-mice）, which overexpress simian virus 40 （SV40） TAg in reproductive organs, and the resulting individuals were evaluated. Survival was evaluated with a cutoff of 24 weeks. Indicators of tumor size （testicular diameter in males, abdominal circumference in females） and body weights were evaluated at 12–13 weeks.
Results: There were no significant differences in survival between CAG-mCbr1/mOvgp1-TAg double Tg （dTg）-mice and mOvgp1-TAg Tg-mice （P = 0.992）. Male CAG-mCbr1/mOvgp1-TAg dTg-mice tended to have higher survival rates than in mOvgp1-TAg Tg-mice. Although, female mOvgp1-TAg Tg-mice tended to have higher survival rates than for CAG-mCbr1/mOvgp1-TAg dTg-mice, female body weights and male testicular diameter tended to be larger in mOvgp1-TAg Tg-mice than in WT mice.
Conclusions: The lack of significant differences may be attributed to the strong carcinogenic effect of SV40 T-antigen. Although whether CBR1 has antitumor effects was not established, it may be involved in tumor growth rather than in metastasis. |
|
言語 |
en |
| 書誌情報 |
ja : 弘前医学
en : Hirosaki Medical Journal
巻 74,
号 1-4,
p. 99-107,
発行日 2024-03-28
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-4656 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科 |
|
言語 |
ja |
| 資源タイプ |
|
|
言語 |
en |
|
値 |
Article |
Hirosaki Med J 74-1-4_99.pdf (1.3 MB)
