| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-04-29 |
| タイトル |
|
|
タイトル |
Diamidobenzimidazole, an agonist of STING, induces the expression of retinoic acid-inducible gene-I and interferon-induced transmembrane protein 1 in BEAS-2B cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
STING |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
RIG-I |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IFITM1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
BEAS-2B |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Mami, Sato
Tadaatsu, Imaizumi
Jiangli, Ding
Kazuhiko, Seya
Shogo, Kawaguchi
Yusuke, Tanaka
Yasushi, Matsuzaki
Tomoh, Matsumiya
Atsushi, Matsubara
|
| 著者所属 |
|
|
|
en |
|
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Department of Otorhinolaryngology Head and Neck Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
en |
|
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
en |
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
en |
|
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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|
en |
|
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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en |
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Department of Respiratory Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
en |
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Department of Dermatology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
en |
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Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences |
| 著者所属 |
|
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|
en |
|
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Department of Otorhinolaryngology Head and Neck Surgery, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The bronchial epithelium is the site of initial exposure in lungs to viruses, including severe acute respiratory syndrome coronavirus 2. Stimulator of interferon genes （STING） is a molecule activated by virus-derived DNA. STING activation leads to the induction of type I interferon （IFN） expression, followed by increased expression of IFN-stimulated genes （ISGs）. Retinoic acid-inducible gene-I （RIG-I） and IFN-induced transmembrane protein 1 （IFITM1） are ISGs important in antiviral immunity. However, the interaction between STING and RIG-I/ IFITM1 in bronchial epithelium is not fully understood. We found that the STING agonist diamidobenzimidazole （diABZI） upregulated RIG-I and IFITM1 expression in BEAS-2B. Knockdown of STING decreased diABZI-induced IFN-βexpression and the phosphorylation of signal transducer and activator of transcription （STAT） 1, while treatment with recombinant human IFN-β upregulated the expression level of RIG-I and IFITM1. These data indicate that activation of STING/IFN-β axis upregulates the levels of RIG-I and IFITM1 in bronchial epithelium, activating RNA virus sensing pathway, inhibiting virus entry into cells. This study contributes to the discovery of new therapeutic targets for upper airway infections caused by viruses. |
|
言語 |
en |
| 書誌情報 |
ja : 弘前医学
en : Hirosaki Medical Journal
巻 74,
号 1-4,
p. 117-127,
発行日 2024-03-28
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-4656 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科 |
|
言語 |
ja |
| 資源タイプ |
|
|
言語 |
en |
|
値 |
Article |
Hirosaki Med J 74-1-4_117.pdf (490 KB)
