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アイテム
Tryptophan metabolism and small fibre neuropathy: a correlation study
http://hdl.handle.net/10129/0002000717
http://hdl.handle.net/10129/000200071782762329-f44d-4915-8f3d-0b9a6010fad2
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本文 (995 KB)
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内容要旨 (179 KB)
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審査要旨 (510 KB)
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| Item type | リポジトリ登録用アイテムタイプ（シンプル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-12-25 | |||||||
| タイトル | ||||||||
| タイトル | Tryptophan metabolism and small fibre neuropathy: a correlation study | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | pain | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | UDC | |||||||
| 主題 | diabetic polyneuropathy | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | small fibre neuropathy | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | metabolomics | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | tryptophan | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子（シンプル） | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ（シンプル） | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
櫛引, 英恵
× 櫛引, 英恵
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Small nerve fibres located in the epidermis sense pain. Dysfunction of these fibres decreases the pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting small fibre neuropathy. These findings suggest that various metabolic changes may be involved in small fibre neuropathy. Herein, we explored the correlation between pain sensation and changes in plasma metabolites in healthy Japanese subjects. The pain threshold evaluated from the intraepidermal electrical stimulation was used to quantify pain sensation in a total of 1021 individuals in the 2017 Iwaki Health Promotion Project. Participants with a pain threshold evaluated from the intraepidermal electrical stimulation index <0.20 mA were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation index-low group (n = 751); otherwise, they were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation indexhigh group (n = 270). Metabolome analysis of plasma was conducted using capillary electrophoresis time-of-flight mass spectrometry. The metabolite set enrichment analysis revealed that the metabolism of tryptophan was significantly correlated with the pain threshold evaluated from the intraepidermal electrical stimulation index in all participants (P < 0.05). The normalized level of tryptophan was significantly decreased in participants with a high pain threshold evaluated from the intraepidermal electrical stimulation index. In addition to univariate linear regression analyses, the correlation between tryptophan concentration and the pain threshold evaluated from the intraepidermal electrical stimulation index remained significant after adjustment for multiple factors (β = −0.07615, P < 0.05). These findings indicate that specific metabolic changes are involved in the deterioration of pain thresholds. Here, we show that abnormal tryptophan metabolism is significantly correlated with an elevated pain threshold evaluated from the intraepidermal electrical stimulation index in the Japanese population. This correlation provides insight into the pathology and clinical application of small fibre neuropathy. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author: Hanae Kushibiki, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Takanori Sasaki, Saori Ogasawara, Kanichiro Wada, Shin Midorikawa, Masaki Ryuzaki, Zhenchao Wang, Takahiro Yamada, Keisuke Yamazaki, Takefusa Tarusawa, Taiyo Tanba, Tatsuya Mikami, Atsushi Matsubara, Yasuyuki Ishibashi, Kenichi Hakamada and Shigeyuki Nakaji | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Brain communications, 6(2):fcae103; 2024 | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : Brain Communications 巻 6, 号 2, p. 103, 発行日 2024-03-25 |
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| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2632-1297 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1093/braincomms/fcae103 | |||||||
| 権利情報 | ||||||||
| 言語 | en | |||||||
| 権利情報 | © The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 出版者 | ||||||||
| 出版者 | Oxford University Press | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士（医学） | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 11101 | |||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 弘前大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2024-09-30 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第2292号 | |||||||
