WEKO3
アイテム
Epilepsy, Pregnancy and Antiepileptic Drugs
http://hdl.handle.net/10129/2040
http://hdl.handle.net/10129/2040f5da2b1e-b93c-43a5-b30b-859838b7a4df
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_38(3)_434.pdf (1.3 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2009-07-17 | |||||||
| タイトル | ||||||||
| タイトル | Epilepsy, Pregnancy and Antiepileptic Drugs | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | malformation | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | seizure frequency | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | compliance | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | hormone | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | folic acid | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 著者 |
Kaneko, Sunao
× Kaneko, Sunao
|
|||||||
| 著者(ヨミ) | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 9355 | |||||||
| 姓名 | カネコ, スナオ | |||||||
| 著者別名 | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 9351 | |||||||
| 姓名 | 兼子, 直 | |||||||
| 著者所属 | ||||||||
| Department of Neuropsychiatry, Hirosaki University, School of Medicine | ||||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Clinical and basic researches on epilepsy and pregnancy. in particular of antiepileptic drugs (AEDs) on the fetus and the epileptic mother, and those of pregnancy on the course of epilepsy were reviewed. The complete control of seizures in the pregestational period and regular drug taking are very important for better management of pregnant epileptics with medication, since the seizure frequency remains mostly unchanged when the patient's compliance is good. If the serum level decreases, one must confirm the patient's compliance. Once compliance has been established, the dose should be increased only when seizures occur. Most AEDs cross the placenta and some cause unwanted effects on the embryo, the fetus, or the newborn. Thus pre-conceptional counselling should ensure that an epileptic embarks upon a pregnancy with her epilepsy well controlled by a minimal dose of AEDs, and adequate answers for the questions raised by the patient should be given to prevent poor compliance. There is an increased risk of major congenital malformations among the offsprings of women with epilepsy, most of whom are on AEDs. Part of this increase is due to exposure to AEDs. Other factors also appear to play an important role. Prevention of malformation can take place before the onset of the pregnancy by decreasing the dose of the drug and/or changing from a combination of AEDs to a single drug, since there is a dose-response relation for teratogenesis and a greater occurrence of congenital malformation when the mother receives combined AED therapy. An aspect of prenatal growth deficiency that has raised concern is that brain growth may be affected, producing microcephaly and mild to moderate mental retardation. However, the delay in the physical development of the offspring may be transient. The psychomotor retardation continued only through infancy. if they were nursed properly. |
|||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 弘前医学. 38(3), 1986, p.434-456 | |||||||
| 書誌情報 |
弘前医学 巻 38, 号 3, p. 434-456, 発行日 1986-09 |
|||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0439-1721 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00211444 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 日本十進分類法 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 493.7 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | てんかん, 妊娠, 抗てんかん薬 | |||||||
| タイトル（ヨミ） | ||||||||
| その他のタイトル | テンカン ニンシン コウテンカンヤク | |||||||
| NIIサブジェクト | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 内科系臨床医学 | |||||||
| 出版者 | ||||||||
| 出版者 | 弘前大学医学部 | |||||||
| 資源タイプ | ||||||||
| 値 | Article | |||||||
