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EFFECT OF FENOFIBRATE ON LIPID LEVELS OF TYPE 2 DIABETIC PATIENTS WITH DYSLIPIDEMIA
http://hdl.handle.net/10129/63
http://hdl.handle.net/10129/630ce05ca3-2c40-409c-8f78-7aa292fc1cf2
名前 / ファイル | ライセンス | アクション |
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KJ00004100950.pdf (488.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-12-06 | |||||
タイトル | ||||||
タイトル | EFFECT OF FENOFIBRATE ON LIPID LEVELS OF TYPE 2 DIABETIC PATIENTS WITH DYSLIPIDEMIA | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | small | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dence LDL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | remnant lipoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | remnant-like particle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 小型高比重LDL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | レムナントリポ蛋白 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | レムナント粒子 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
村上, 宏
× 村上, 宏× 玉澤, 直樹× 大和, 一美× 田辺, 壽太郎× 葛西, 伸彦× 松井, 淳× 管, 静芝× 小川, 吉司× 須田, 俊宏 |
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著者(ヨミ) | ||||||
姓名 | ムラカミ, ヒロシ | |||||
著者(ヨミ) | ||||||
姓名 | タマサワ, ナオキ | |||||
著者(ヨミ) | ||||||
姓名 | ヤマト, カズミ | |||||
著者(ヨミ) | ||||||
姓名 | タナベ, ジュタロウ | |||||
著者(ヨミ) | ||||||
姓名 | カサイ, ノブヒコ | |||||
著者(ヨミ) | ||||||
姓名 | マツイ, ジュン | |||||
著者(ヨミ) | ||||||
姓名 | オガワ, ヨシジ | |||||
著者(ヨミ) | ||||||
姓名 | スダ, トシヒロ | |||||
著者別名 | ||||||
姓名 | Murakami, Hiroshi | |||||
著者別名 | ||||||
姓名 | Tamasawa, Naoki | |||||
著者別名 | ||||||
姓名 | Yamato, Kazumi | |||||
著者別名 | ||||||
姓名 | Tanabe, Jutaro | |||||
著者別名 | ||||||
姓名 | Kasai, Nobuhiko | |||||
著者別名 | ||||||
姓名 | Matsui, Jun | |||||
著者別名 | ||||||
姓名 | Guan, Jing-Zhi | |||||
著者別名 | ||||||
姓名 | Ogawa, Yoshiji | |||||
著者別名 | ||||||
姓名 | Suda, Toshihiro | |||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
Third Department of Internal Medicine, Hirosaki University School of Medicine | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
著者所属 | ||||||
弘前大学医学部第三内科 | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of fenofibrate in type 2 diabetic patients with dyslipidemia was examined. Thirteen patients with type 2 diabetes mellitus and mixed hyperlipidemia; serum total cholesterol (TC)>220 mg/dl and/or triglyceride (TG)>150 mg/dl, were included in the study. Fenofibrate was administered at daily dose from 200 to 300 mg, and following items were implemented just prior to, at 3 months after, and at 6 months after the administration: amount of serum lipid, electrophoresis of lipoprotein by the method of polyacrylamide gel electrophoresis (PAGE), quantification of cholesterol (RLP-C) and triglyceride (RLP-TG) in remnant-like particle. TC significantly decreased at 6 months after administration (p<O.05), while TG at 3 and 6 months after administration was significantly lowered (p<0.05). Concentration of RLP-C that was 16.3 mg/dl before administration of fenofibrate decreased with statistical significance to attain 6.2 mg/dl and 7.2 mg/dl in 3 and 6 months after administration, respectively (p<0.01). In the case of RLP-TG, the concentration of 92.2 mg/dl before administration was observed to be lowered with time with statistical significance to reach 28.7 mg/dl and 32.7 mg/dl in 3 and 6 months, respectively (p<0.01). The low-density lipoprotein (LDL) particle size significantly increased at 6 months after administration (p<0.05). In all cases the remnant lipoprotein was observed on PAGE before administration, the bands disappeared or decreased in 8 cases by the treatment with fenofibrate. It was suggested that fenofibrate lowered RLP-C and RLP-TG, and improved the LDL particle size in type 2 diabetics with dyslipidemia. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 55(3/4), 2004, 101-107 | |||||
書誌情報 |
弘前医学 巻 55, 号 3/4, p. 101-107, 発行日 2004-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
その他のタイトル | ||||||
その他のタイトル | 脂質代謝異常を呈する2型糖尿病患者に対するフェノフィブラートの効果 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | シシツ タイシャ イジョウ オ テイスル 2ガタ トウニョウビョウ カンジャ ニ タイスル フェノフィブラート ノ コウカ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学医学部・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |