| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
|
|
タイトル |
The role of NEDD8 Ultimate Buster 1, NUB1, in neurodegenerative α-synucleinopathies |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
α-synucleinopathies |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ubiquitin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
NEDD8 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tanji, Kunikazu
Mori, Fumiaki
Takahashi, Hitoshi
Kamitani, Tetsu
Wakabayashi, Koichi
|
| 著者所属 |
|
|
|
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Pathology, Brain Research Institute, University of Niigata, Niigata |
| 著者所属 |
|
|
|
Department of Cardiology, The University of Texas |
| 著者所属 |
|
|
|
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
NEDD8 is developmentally down-regulated ubiquitin-like protein, which can conjugate covalently to their target proteins. Recently, we identifi ed NUB1 as a NEDD8-interacting protein, which is composed of 601 amino acid residues with a calculated molecular mass of 69.1 kDa. More recently, we showed that NUB1 is an interferon-induced protein and also recruits NEDD8 to the proteasome for degradation. Here, we performed a yeast two-hybrid screening using NUB1 as bait and isolated the cDNA of synphilin-1 from a human testis cDNA library. Synphilin-1 is a major component of inclusion bodies found in the brains of patients with α-synucleinopathies, including Parkinson’s disease. Our biochemical study showed that NUB1 directly interacts with synphilin-1 through its NEDD8-binding site. In addition, our immunohistochemical study showed that NUB1, as well as synphilin-1, accumulates in the inclusion bodies found in the brains of patients with α-synucleinopathies. These fi ndings imply that NUB1 plays a role in the formation of synphilin-1-positive inclusions. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S143-S146 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S143-S146,
発行日 2007-11-29
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491.4 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S143.pdf (641.9 kB)
