| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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|
タイトル |
The relations of lung injury after cardiopulmonary bypass and infl ammatory reaction, especially neutrophil elastase |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
SIRS |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cardiopulmonary bypass |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cardiac surgery |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neutrophil elastase |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Yasuyuki
Daitoku, Kazuyuki
Minakawa, Masahito
Fukui, Kozo
Fukuda, Ikuo
|
| 著者所属 |
|
|
|
Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
We have proved that Sivelestat preserved lung function after cardiopulmonary bypass（ CPB） in the rabbit model. We now report the therapeutic efficacy of Sivelestat in the clinical case. From July 2005, 16 patients who underwent aortic arch replacements were enrolled in this study. Diagnosis included dissected aortic aneurysm in 6 patients, true aortic arch aneurysm in 8, and traumatic aortic arch aneurysm in 1 patient. We randomly divided these patients into two groups. In the Pre-Group（ Pre:n=8）, infusion of Sivelestat（ 0.2mg/kg/hr） was started before the operation; in the Post-Group（ Post:n=8）, it was started after the operation. Serum elastase activity, interleukin-8（ IL-8） levels were measured before the operation, before cessation of CPB and at the end of operation. Blood gas analyses were measured before the operation, at one and three hours after the CPB and the next morning. Because the preoperative P/F ratio（ arterial PO2/FiO2） varies with each case, the value of the P/F ratio at one hour after the CPB was calculated for 100%. Elastase activity of both groups were increased at the end of CPB（ Pre:8.9±10.6, Post:4.6± 3.5）, then returned to baseline level at end of operation（ NS）. IL-8 of both groups were increased at end of CPB, then in the Pre-Group decreased to 59.3± 25.0 pg/ml, but in the Post-Group increased to 97.9±45.7 pg/ml（ p=0.09）. The P/F ratio in the Pre- Group was well maintained from post CPB to next morning, but in the Post-Group was decreased three hours after the CPB （p<0.05）. In conclusion, these fi ndings showed that Sivelestat reduced the infl ammatory reaction associated with cardiopulmonary bypass, and prevented the pulmonary dysfunction caused by infl ammatory reaction. |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S147-S153 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S147-S153,
発行日 2007-11-29
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
|
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
494 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
外科系臨床医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S147.pdf (305.5 kB)
